ReviewFrontiers in immunology2026
Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Age-related osteoporosis arises from the interplay between impaired bone remodeling, immune remodeling, and chronic low-grade inflammation during aging. Beyond local degeneration in bone tissue, alterations in the gut microbiota, mucosal barrier, and autonomic nervous regulation may reshape the bone marrow immune environment and amplify osteoclastogenic responses. This review integrates evidence linking the gut, neural regulation, and the bone marrow immune microenvironment. It summarizes their potential contributions to age-related bone loss and provides a conceptual framework for understanding disease mechanisms, improving risk stratification, and optimizing intervention strategies.
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