Evidence map›Paper›PMID 42871486›Full record

ArticleMedComm2026

Blocking Extracellular Cyclophilin A-Mediated Adhesion Protects Against Bacterial Infection.

Xiaoyuan Bai, Heqiao Li, Pengtao Jiao, Yuna Zhao, Xiaoxiao Jia, Han Zhong Pei, Zeqiu Fan, Runshan Lin, He Zhang, Beinan Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaoyuan Bai *Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Heqiao Li *Institute of Infectious Diseases Shenzhen Bay Laboratory Shenzhen China.
Pengtao Jiao *Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Yuna Zhao *Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Xiaoxiao JiaKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Han Zhong PeiInstitute of Infectious Diseases Shenzhen Bay Laboratory Shenzhen China.
Zeqiu FanKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Runshan LinShenzhen Medical Academy of Research and Translation (SMART) Shenzhen China.
He ZhangShenzhen Medical Academy of Research and Translation (SMART) Shenzhen China.
Beinan WangKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Xinhai ChenInstitute of Infectious Diseases Shenzhen Bay Laboratory Shenzhen China.
Yuhai BiKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
De ChangDepartment of Pulmonary and Critical Care Medicine at The Seventh Medical Center College of Pulmonary and Critical Care Medicine of The Eighth Medical Center Chinese PLA General Hospital Beijing China.
Zhongfa ZhangPublic Health Clinical Center Affiliated to Shandong University Shandong Public Health Clinical Center Jinan China.
Yuxin ChenDepartment of Laboratory Medicine Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School Nanjing University Nanjing China.
Wenjun LiuKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.
Lei SunKey Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial pneumonia remains a leading cause of mortality and morbidity worldwide and is primarily managed through antibiotic therapy. However, the increasing threat of antimicrobial resistance underscores the urgent need for alternative strategies. In this study, we identify extracellular cyclophilin A (eCypA) as a key host factor that promotes the adherence of bacteria such as group A

Indexed as

adhesion receptorbacterial infectioncyclophilin Ahost‐directed therapyinflammatory responseTGF‐β

Identifiers

PMID42871486
PMCPMC13659286

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.