ReviewFrontiers in bioengineering and biotechnology2026
Advances in iron-storage protein-based MRI reporter genes: from molecular mechanisms to translational imaging applications.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-invasive monitoring of cellular and molecular events is essential for advancing precision medicine. While exogenous probes often suffer from signal dilution, iron-storage protein-based MRI reporter genes offer an alternative for longitudinal tracking, because contrast is regenerated by the cells themselves. Especially ferritin and its engineered variants have attracted growing interest due to their ability to regulate intracellular iron and generate endogenous T2/T2* contrast. This review summarizes the molecular mechanisms and design principles of iron-based MRI reporter genes, and examines recent developments including CRISPR-mediated integration and manganese-dependent "Bright Ferritin" platforms, which generate positive T1 contrast but require repeated administration of exogenous manganese. Preclinical studies have tracked cellular dynamics
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