ArticleFrontiers in nuclear medicine2026
Absolute stress myocardial blood flow is reduced in patients with prior cardiac disease despite normal perfusion and ejection fraction on rubidium-82 PET: an Arabian Gulf cohort.
Article in Frontiers in nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Rubidium-82 (⁸ Patients and methods: This retrospective single-centre study included 292 source-verified patients (mean age 63.1 ± 12.1 years; 56.8% male) who underwent adenosine-stress ⁸ Results: Among normal-appearing studies, patients with prior cardiac disease had lower global stress MBF (2.25 vs. 2.99 mL/min/g; d = -0.78, 95% CI -1.22 to -0.33) and lower RCA stress MBF (2.25 vs. 3.29; d = -1.02, -1.47 to -0.56); rest MBF was also lower (d = -0.47, -0.91 to -0.04), whereas MFR (d = -0.37, -0.80 to 0.07), LVEF and LV volumes did not differ. In the secondary comparison, stress MBF and MFR separated the predefined categories comparably (DeLong Z = 0.89, Conclusions: In this Arabian Gulf cohort, patients with prior cardiac disease had lower absolute stress MBF despite normal perfusion category and ejection fraction. These exploratory findings support further prospective evaluation of absolute stress MBF as an adjunct to conventional PET interpretation. Because rest and stress flow fell together with a preserved ratio, and because haemodynamic, medication and infarct-related explanations could not be excluded, no mechanism is inferred.
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