ArticleAME case reports2026
Possible Epstein-Barr virus-associated central nervous system involvement with reversible electroencephalographic abnormalities in a child: a case report.
Article in AME case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background: Epstein-Barr virus (EBV)-associated central nervous system (CNS) involvement in children is uncommon and may present with nonspecific neurological symptoms. Brain magnetic resonance imaging (MRI) may remain normal, making diagnosis challenging. Cerebrospinal fluid (CSF) targeted next-generation sequencing (tNGS) has emerged as a useful diagnostic tool, although positive EBV results require careful clinical interpretation. Case Description: A previously healthy 5-year-old boy presented with fever (38.5 ℃), headache, dizziness, and nausea for 3 days without seizures, altered consciousness, focal neurological deficits, or ataxia. Laboratory tests showed leukocytosis and elevated inflammatory markers. Brain MRI was unremarkable. CSF examination revealed an opening pressure of 120 mmH Conclusions: This case highlights that possible EBV-associated CNS involvement may occur in children despite normal brain MRI and only mild CSF abnormalities. The combination of CSF tNGS, dynamic EBV serology, EEG findings, exclusion of alternative etiologies, and clinical follow-up may facilitate diagnosis. Because EBV detected in CSF does not necessarily indicate causation, results should always be interpreted in the context of the overall clinical presentation.
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