ArticleFrontiers in behavioral neuroscience2026
Long-term sugar consumption alters extracellular dopamine and acetylcholine levels in the nucleus accumbens shell.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
High dietary sugar consumption is associated with an increased risk of various diseases, making it imperative to identify the neural, nutritional, and behavioral mechanisms that underlie dietary habits to better understand and improve health. However, little is known about the neural mechanisms underlying prolonged consumption, making it difficult to determine the alterations caused by chronic sucrose intake in reinforcement and memory pathways, including the nucleus accumbens. Previous work in rodents has shown that long-term sugar consumption alters appetitive relearning, potentially leading to increased intake due to a disability in learning new negative consequences associated with the same taste, which possibly involves the mesolimbic dopaminergic system as well as cholinergic signaling. The objective of this study was to evaluate the extracellular levels of dopamine (DA) and acetylcholine (ACh) in the nucleus accumbens shell (NACsh) of adult male Wistar rats during novel (SN), familiar sugar consumption (2 days, SF), and after exposure
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