ArticleFrontiers in public health2026
Sexual dysfunction, depressive symptoms, and perceived impact of HBV infectivity among noncirrhotic patients with chronic hepatitis B: a cross-sectional study.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic hepatitis B (CHB) remains a major global public health burden, yet sexual health is rarely addressed in routine care. This study aimed to assess the prevalence of sexual dysfunction (SD) and examine demographic, clinical, and psychological factors associated with sexual function among noncirrhotic patients with CHB. We also explored the association between sexual function and the perceived negative impact of HBV infectivity on sexual life. Methods: This cross-sectional study was conducted from December 2023 to July 2024, enrolling 657 patients with CHB and 121 non-HBV controls. Patients with CHB were classified by treatment status as receiving pegylated interferon α-2b ( Results: The prevalence of SD was significantly higher in all CHB subgroups than in Non-HBV group, with the highest prevalence observed in the IFN-CHB group, both in men (70.9%) and women (70.8%). In multivariable models, older age, IFN-CHB status, and higher PHQ-9 scores were associated with lower sexual function scores in both sexes. Of the variables examined, IFN-CHB status showed the strongest negative association in men ( Conclusion: Sexual dysfunction was common among sexually active patients with CHB, and poorer sexual function was associated with IFN-CHB status, depressive symptoms, and the perceived negative impact of HBV infectivity on sexual life. Sexual health assessment and mental health support may therefore have value in comprehensive CHB care.
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