ArticleFrontiers in cell and developmental biology2026
TRPV4-linked oxidative-lysosomal stress in myocardial ischemia/reperfusion: disease-matched transcriptomics and functional analysis in OGD/R cardiomyoblasts.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Myocardial ischemia/reperfusion (MI/R) injury involves oxidative stress, lysosomal dysfunction, and altered autophagy. TRPV4 may link Ca Methods: Three disease-matched mouse-heart GEO cohorts (GSE281940, GSE130217, and GSE160516) were analyzed using limma-based differential expression, prespecified oxidative, lysosomal, and autophagy-related gene sets, cross-cohort comparisons, and within-cohort correlations. H9C2 cardiomyoblasts subjected to OGD/R were used to examine intracellular Ca Results: All three cohorts showed clear MI/R-associated transcriptional changes. Hmox1 was consistently increased across all five prespecified contrasts, whereas Conclusion: The transcriptomic data indicate a context-dependent TRPV4 response within a conserved MI/R stress background. The H9C2 cardiomyoblasts experiments support the involvement of the TRPV4-ROS-LMP pathway in lysosomal injury, impaired autophagic degradation, inflammatory responses, and OGD/R-induced cardiomyoblast injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.