ArticleFrontiers in immunology2026
X-linked hyper IgM syndrome with a novel CD40-ligand gene mutation suffered from infection of Talaromyces marneffei.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: X-linked Hyper-IgM Syndrome (X-HIGM) is a primary immunodeficiency caused by pathogenic variants in Methods: We report a 4-year-old Chinese girl who developed disseminated Talaromyces marneffei infection and was subsequently diagnosed with X-HIGM. Her clinical history and laboratory findings were reviewed, and a comprehensive immunological evaluation was performed, including flow cytometric analysis. Genetic testing was carried out by next-generation sequencing, and the identified variant was confirmed by Sanger sequencing. The possible effect of the Results: A previously undescribed heterozygous Discussion: We identified a
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