Evidence map›Paper›PMID 42871081›Full record

ArticleBiochemistry and biophysics reports2026

Hybrid spheroids of urine-derived renal epithelial cells: Structural and functional characterization.

Valeria Pizzuti, Emma Balducelli, Sofia Bin, Marcello Demetri, Diletta Conte, Francesco Alviano, Francesca Paris, Miriam Di Nunzio, Elisa Gessaroli, Anna Mistretta and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valeria PizzutiNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40139, Italy.
Emma BalducelliDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Sofia BinDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Marcello DemetriNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40139, Italy.
Diletta ConteDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Francesco AlvianoCellular Signalling Laboratory, Anatomy Center, Department of Biomedical Sciences (DIBINEM), University of Bologna, Bologna, 40126, Italy.
Francesca ParisCellular Signalling Laboratory, Anatomy Center, Department of Biomedical Sciences (DIBINEM), University of Bologna, Bologna, 40126, Italy.
Miriam Di NunzioDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Elisa GessaroliDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Anna MistrettaDepartment of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy.
Valeria CorradettiNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40139, Italy.
Gaetano La MannaNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40139, Italy.
Giorgia ComaiNephrology, Dialysis and Kidney Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, 40139, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urine-derived Renal Epithelial Cells (URECs) are voided in urine after acute kidney damage and in response to ischemia reperfusion events. We previously investigated the phenotype and immunomodulatory properties of URECs derived from kidney transplanted patients. Here, we establish a 3D model combining URECs with Wharton's Jelly Mesenchymal Stromal Cells (WJ-MSCs), to evaluate structure, cell distribution and viability of the spheroids. Immunomodulatory properties were analysed by coculturing spheroids with Peripheral Blood Mononuclear Cells (PBMCs); CD4

Indexed as

3D modelsImmune responseImmunomodulationSpheroidsUrine derived cells

Identifiers

PMID42871081
PMCPMC13658127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.