Evidence map›Paper›PMID 42871064›Full record

Observational studyFrontiers in public health2026

The associations between dynapenic obesity and cognitive disorder in older hypertension patients: a multicenter cross-sectional study.

Pingping An, Juxiao Wu, Yijing Zhang, Zhanlei Shen, Yudong Miao, Jian Wu, Quanman Li

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Pingping AnDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.
Juxiao WuKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, United States.
Yijing ZhangDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.
Zhanlei ShenDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.
Yudong MiaoDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.
Jian WuDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.
Quanman LiDepartment of Health Policy and Management, College of Public Health, Zhengzhou University, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence regarding the associations between dynapenic obesity and cognitive disorder in older adults is limited. This study aimed to investigate the prevalence of cognitive disorder among the older patients with hypertension (HTN), explore the association between dynapenic obesity and cognitive disorder, and explore a hypothesized path structure. Methods: We conducted a multicenter cross-sectional study from July 2023 to March 2024 among the older HTN patients aged 65 years and older. Data were collected using a structured questionnaire and standardized measurement. Logistic regression models were used to test the association between dynapenic obesity and cognitive disorder. Multiple imputation by chained equations under a missing-at-random assumption was conducted. Structural equation modeling was employed to explore the hypothesized path analysis. Subgroup and sensitivity analyses were performed to validate the robustness of the findings. Results: The study included 9,568 older HTN patients. The prevalence of cognitive disorder in this population was 15.67% (95% confidence interval [CI]: 14.94-16.40%). After adjusting for potential confounders, a significant positive association was observed between dynapenic obesity and cognitive disorder (adjusted odds ratio [aOR] = 1.418, 95% CI: 1.263-1.591). In the path model, dynapenic obesity was associated with lower odds of adequate physical activity (PA) (aOR = 0.708, 95% CI: 0.640-0.783). Adequate physical activity was associated with lower odds of depressive disorders (aOR = 0.441, 95% CI: 0.367-0.529) and cognitive disorder (aOR = 0.521, 95% CI: 0.452-0.601). Participants with depressive disorders had higher odds of cognitive disorder than those without depressive disorders (aOR = 1.312, 95% CI: 1.031-1.669). This association remained consistent across different age groups (all Conclusion: Dynapenic obesity was positively associated with cognitive disorder. PA and depressive disorders were regarded as variables within a hypothesized cross-sectional path structure.

Indexed as

Cognition DisordersHypertensionObesityAgedAged, 80 and overChinaCross-Sectional StudiesFemaleHumansMalePrevalencecognitive disorderdepressive disordersdynapenic obesityhypertensionolder adultspath analysisphysical activity

Identifiers

PMID42871064
PMCPMC13657995

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