Observational studyFrontiers in neurology2026
Serum NLRP3 levels are associated with postoperative delirium of elderly patients with lung cancer: an observational analytical study.
Observational study in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: NOD-like receptor protein 3 (NLRP3) regulates the inflammatory response. This study aimed to investigate the relationship between perioperative serum NLRP3 levels and postoperative delirium (POD) in elderly patients with lung cancer. Methods: In this observational analytical study, serum NLRP3 levels were measured preoperatively and postoperatively in 266 elderly patients with lung cancer and at study entry in 100 controls. We used the American Society of Anesthesiologists (ASA) Scale, Charlson Comorbidity Index (CCI), and Eastern Cooperative Oncology Group (ECOG) Scaleto classify patients' preoperative physical fitness. Patients were assessed for POD from the first to the third postoperative day using the Chinese Confusion Assessment Method. Predictors of POD were determined using multivariate analysis. Results: Preoperative and postoperative serum NLRP3 levels in patients were significantly higher than those in controls, with the highest levels observed postoperatively. Postoperative blood C-reactive protein levels and ECOG scores were independently correlated with postoperative serum NLRP3 levels. Postoperative serum NLRP3 levels, ASA classifications, and CCI were independently associated with POD. The nomogram model incorporating the three independent predictors of POD was confirmed to have good discrimination, calibration, and clinical utility based on the receiver operating characteristic curve, calibration curve, and decision curve. Compared with the clinical model (CCI + ASA), the nomogram model demonstrated significant improvement in risk reclassification, with a continuous NRI of 0.7198 (95% CI, 0.4366-1.003) and an IDI of 0.0867 (95% CI, 0.041-0.1323); however, the improvement in AUC did not reach statistical significance. Internal validation through 10-fold cross-validation demonstrated that the nomogram model had good predictive accuracy based on the optimism-corrected area under the curve. Conclusion: Significantly increased postoperative serum NLRP3 levels are independently associated with POD in elderly patients with lung cancer, and the model integrating serum NLRP3 levels shows favorable predictive performance for POD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.