Trial reportFrontiers in neurology2026
Effects of single-modality sensory stimulation on brain function in patients with prolonged disorders of consciousness: a near-infrared spectroscopy-based study.
Trial report in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Objective: To explore the effects of four single-modality sensory stimulations on the brain functional networks in patients with prolonged disorders of consciousness (pDOC), and to clarify the correlation between different sensory stimulations and the improvement of patients' consciousness level, so as to provide references for clinical treatment and rehabilitation of pDOC patients. Methods: A prospective, multicenter, randomized controlled trial design was adopted. A total of 57 patients with pDOC were enrolled and divided into visual stimulation group, auditory stimulation group, olfactory-gustatory stimulation group, somatosensory-nocieptive stimulation group, and control group. The intervention duration of each group was 15 min. Behavioral assessments were performed using the Coma Recovery Scale-Revised (CRS-R) and Glasgow Coma Scale (GCS). Combined with functional near-infrared spectroscopy (fNIRS), hemodynamic parameters and brain functional connectivity were detected. Changes in brain function and consciousness level before and after different sensory stimulation interventions were evaluated. Results: Visual, auditory and olfactory-gustatory stimulations induced significant and robust alterations in cerebral activity across most detected channels ( Conclusion: Single-modality sensory stimulation elicits acute cerebral activation in pDOC patients, which is superior to conventional rehabilitation alone. Visual and auditory stimulations exert significantly better intervention effects than olfactory-gustatory and somatosensory-nocieptive stimulations. Among olfactory-gustatory interventions, acetic acid stimulation produces prominent brain region activation, and ethanol enhances functional connectivity of related brain regions. Both can serve as an effective supplementary intervention for pDOC patients with visual and auditory dysfunction, and possess important value for further research and clinical application in the management of pDOC.
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