SynthesisFrontiers in cellular and infection microbiology2026
Inflammatory and immune pathways in Ménière's disease: a multi-database bibliometric and visualized analysis of research trends.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ménière's disease (MD) is a chronic inner ear disorder characterized by recurrent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Growing evidence indicates that aberrant immune regulation, inflammation, and allergic reactions are involved in the development of MD. However, a systematic synthesis of the current research landscape and evolving hotspots in this field remains lacking. Methods: Publications concerning immune-inflammatory mechanisms in MD published between 1 January 2006 and 31 December 2025 were retrieved from the Web of Science Core Collection and Scopus databases. Bibliometric and visual analyses were performed using R-bibliometrix, VOSviewer, CiteSpace, and Python. Results: A total of 868 publications were included in this study, with annual output showing a sustained upward trend. The United States, China, and Italy were the major contributing countries. Core journals and research teams in this field have been predominantly concentrated in the areas of otology, neuro-otology, and vestibular medicine. Research hotspots have progressively shifted from clinical phenotypes, endolymphatic hydrops, and local therapeutic interventions toward immune-inflammatory mechanisms, encompassing cytokine networks, innate immune signaling, allergy-related pathways, and imaging-based phenotypes. Among these, the IL-1β/TNF-α axis, the NF-κB/TLR signaling pathway, and IgE-mediated immune responses have emerged as prominent research directions. Conclusions: This study systematically delineates the global research landscape, knowledge structure, and evolving hotspots in the field of immune-inflammatory research in MD. The findings highlight major research themes and emerging trends, providing a comprehensive research landscape that may help prioritize future investigations into disease mechanisms, biomarker validation, patient stratification, and immune-targeted therapeutic approaches in MD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.