Evidence map›Paper›PMID 42870893›Full record

ArticleTranslational lung cancer research2026

Bioelectrical impedance-derived body composition and systemic therapy outcomes in non-small cell lung cancer.

Xin Zheng, Rui Gao, Boao Jiang, Yihai Wei, Jingwen Diao, Bo Cheng, Jianfu Li, Jingting Su, Yuejiao Su, Wenhai Fu and 4 more

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Article in Translational lung cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xin ZhengDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Rui GaoDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Boao JiangDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yihai WeiDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jingwen DiaoDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Bo ChengDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jianfu LiDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jingting SuDepartment of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.
Yuejiao SuDepartment of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.
Wenhai FuDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Peiling ChenDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xianzhe FanDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenhua LiangDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ying DengDepartment of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Body mass index (BMI) cannot distinguish skeletal muscle from adipose tissue or capture fat distribution in non-small cell lung cancer (NSCLC). We explored whether bioelectrical impedance analysis (BIA)-assessed body composition was associated with systemic therapy outcomes. Methods: Consecutive adults with confirmed NSCLC who underwent pretreatment multifrequency BIA between March 2023 and March 2025 were retrospectively included. Analyses were performed by treatment context, including stage I surgical patients and stage II-IV patients receiving immune checkpoint inhibitor (ICI)- or epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-based systemic therapy. Body-composition parameters were compared by clinical stage and Results: Among 473 screened patients, 369 were included, comprising 126 with stage I disease and 243 with stage II-IV disease. After predefined exclusions, outcome cohorts included 125 ICI-treated and 43 EGFR-TKI-treated patients. In cross-sectional analyses, adiposity-related parameters were nominally lower in stage II-IV disease than in stage I disease, but these differences did not remain significant after false discovery rate (FDR) correction; no body-composition parameter differed significantly by Conclusions: BIA-assessed skeletal muscle reserve and visceral adiposity were associated with outcomes during ICI-based therapy in men with NSCLC. Higher SMI and lower VFI identified a more favorable clinical profile. Prospective validation is warranted to define the role of BIA-based body-composition assessment in host-related risk stratification during systemic therapy.

Indexed as

bioelectrical impedance analysis (BIA)body compositionepidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)immunotherapyNon-small cell lung cancer (NSCLC)

Identifiers

PMID42870893
PMCPMC13657894

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