ArticleTranslational cancer research2026
Role of podoplanin in tongue squamous cell carcinoma and the regulation of malignant cellular behaviors via the ERK/MMP-2 signaling axis.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The prognostic significance and functional role of podoplanin (PDPN) in tongue squamous cell carcinoma (TSCC) remain incompletely defined. This study investigated PDPN expression, prognostic relevance, effects on malignant cellular behaviors, and involvement of the ERK/MMP-2 signaling axis. Methods: PDPN levels in TSCC and matched surrounding noncancerous tissues were detected via immunohistochemistry. The link between PDPN levels and clinicopathological parameters was analyzed, and the prognostic value of PDPN was evaluated. Functional assays were conducted via Results: PDPN was significantly upregulated in TSCC tissues and correlated with poor differentiation, advanced tumor-node-metastasis (TNM) stage, and lymphatic invasion. Multivariate Cox regression analysis identified PDPN as an independent unfavorable prognostic factor for patients with TSCC. Functional assays revealed that PDPN promoted cell migration, proliferation, and invasion, which were mediated through the ERK/MMP-2 pathway. Conclusions:
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