ArticleTranslational cancer research2026
Lnc-TIM3 promotes acute lymphoblastic leukemia progression through miR-5094-mediated regulation of TIM3.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children and is associated with dysregulated long non-coding RNAs (lncRNAs), some of which may serve as potential biomarkers and therapeutic targets. However, the expression pattern and biological role of Lnc-TIM3 in pediatric ALL remain poorly understood. This study aimed to characterize Lnc-TIM3 expression in pediatric ALL and investigate its functional role and underlying regulatory mechanism, with a particular focus on the Lnc-TIM3/miR-5094/TIM3 axis. Methods: The expression levels of lncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) were measured using reverse transcription quantitative polymerase chain reaction (RT-qPCR). Cell proliferation, DNA synthesis, migration, and invasion capabilities were assessed using Cell Counting Kit-8 (CCK-8) assays, soft-agar colony assays, flow cytometry, and Results: Conclusions:
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