ArticleJournal of clinical laboratory analysis2026
Performance Evaluation of Dry Chemical Colorimetry for Plasma Ammonia Detection on the VITROS 350 Chemistry System.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePlasma ammonia quantitation is one of the most valuable laboratory tests for assessing hepatic function. Accurate measurement is clinically imperative for the diagnosis and management of severe hepatobiliary diseases. This study aimed to comprehensively evaluate the analytical performance of the VITROS dry chemistry system with dry chemical colorimetry for plasma ammonia detection.
methodsA full performance validation was conducted on the VITROS 350 Chemistry System in accordance with the guidelines of the Clinical and Laboratory Standards Institute (CLSI) and the China National Accreditation Service for Conformity Assessment (CNAS). Comparability was performed using the VITROS 350 Chemistry System and VITROS 5600 Integrated System across our center and four external laboratories.
resultsThe VITROS 350 platform demonstrated robust analytical performance for plasma ammonia testing. Precision, accuracy, upper limit of the reportable interval, linearity, and carryover rates were all compliant with both clinical requirements and manufacturer specifications. Comparative analysis revealed strong inter-platform concordance, with results from five concentration levels across five laboratories remaining within predefined allowable limits. Regarding interference, only high concentrations of hemoglobin exerted a clinically significant impact on test results, a finding consistent with established clinical experience and diagnostic expectations.
conclusionThis study validates the reliability of the VITROS dry chemistry system for routine plasma ammonia testing. It provides clinical laboratories with a robust framework for method selection and establishes a framework for future external quality assessment (EQA) based on dry chemistry colorimetry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.