Trial reportStress and health : journal of the International Society for the Investigation of Stress2026
Effects of Mindfulness Therapy on Stress Biomarkers and Psychological Symptoms in Women With Recurrent Pregnancy Loss: A Randomized Clinical Trial.
Trial report in Stress and health : journal of the International Society for the Investigation of Stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Women with recurrent pregnancy loss (RPL) exhibit high levels of depression, anxiety, and stress, which negatively impact their quality of life. This randomized clinical trial evaluated the effects of an eight-week online Mindfulness-Based Intervention (MBI), with weekly one-hour sessions, on psychological and biological markers of stress in 35 women with RPL. Participants were randomly assigned to either the MBI or standard care (control group) and assessed before and after the intervention through salivary biomarkers (cortisol, alpha-amylase, and Immunoglobulin A-IgA) and the validated questionnaires Depression, Anxiety and Stress Scale-21 (DASS-21) and Psychological General Well-Being Index (PGWB-I). No significant time × group interactions were observed for salivary biomarkers, including cortisol (p = 0.672), alpha-amylase (p = 0.342), and IgA (p = 0.148). Participants in the MBI group showed significant reductions in total DASS-21 (p = 0.018), depression (p = 0.026), and stress (p = 0.015) scores, whereas anxiety did not differ significantly between groups (p = 0.121). They also showed robust improvements in overall well-being (p < 0.001) and multiple PGWB-I domains. These findings suggest that MBI may improve self-reported psychological well-being in women with RPL; however, as no significant effects were observed in the primary biomarker outcomes, these secondary psychological findings should be considered exploratory and hypothesis-generating.
trial registrationhttps://ensaiosclinicos.gov.br/rg/RBR-4xc76cr.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.