Evidence map›Paper›PMID 42870271›Full record

ArticleJournal of translational medicine2026

Synergistic effect of gastric microbiome and host genetic factor predispose to gastric cancer.

Tsubasa Shimogama, Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Narumi Yano, Takuya Ohtsu, Ryo Yasuoka, Sanshiro Kobayashi, Naohiro Nakamura, Yu Takahashi and 4 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tsubasa ShimogamaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Tomomitsu TaharaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan. tahara.tom@kmu.ac.jp.ORCID 0000-0002-3474-8274
Takuya ShijimayaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Jumpei YamazakiTranslational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Narumi YanoThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Takuya OhtsuThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Ryo YasuokaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Sanshiro KobayashiThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Naohiro NakamuraThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Yu TakahashiThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Takashi TomiyamaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Yusuke HonzawaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Toshiro FukuiThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Makoto NaganumaThird Department of Internal medicine, Kansai Medical University, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.

Funding

Japan Society for the Promotion of Science 26K18751
6 · The paper itself

Abstract

objectiveComplex interaction between host genetic and environmental factors has a role in Helicobacter pylori (H. pylori)-related gastric tumorigenesis, while involvement of non-Helicobacter pylori gastric microbiome may be also relevant to this process. We aimed to evaluate whether combining the non-Helicobacter pylori gastric microbiome signatures and the gastric cancer (GC) predisposing genetic factors (PSCA rs2294008 and MUC1 rs4072037 polymorphisms) stratify a high GC risk subpopulation in a Japanese cohort.

methodsIn 620 subjects including 219 GC patients and 410 non-cancers, microbiome-based GC risk was defined as the gastric microbiome signatures of 47 GC-predisposing bacteria. Genetic risk of GC was also defined as the presence of PSCA rs2294008 and MUC1 rs4072037 risk alleles. Adding effect of gastric microbiome and genetic factor was evaluated in relation to GC susceptibility, histological degree of gastritis and somatic changes in the gastric mucosa including DNA methylation and telomere shortening.

resultsIndividuals possessing the risk of both microbiome and genotype showed significant risk for developing GC with highest OR (odds ratio, e.g., OR = 23.55 in comparison with non-cancer) compared to individuals having risk microbiome or genotype alone (microbiome, OR = 11.16; genotype, OR = 2.76). The individuals having both risks also showed highest degrees of intestinal metaplasia and DNA methylation, and shortest telomere.

conclusionsOur findings suggested an existence of combined effect of host genetic factor and gastric microbiome predispose to gastric tumorigenesis, that can be used as the diagnostic tool to further stratify a high GC risk subpopulation.

Indexed as

Genetic Predisposition to DiseaseMicrobiotaStomachStomach NeoplasmsAntigens, NeoplasmDNA MethylationFemaleGPI-Linked ProteinsHumansMaleMiddle AgedMucin-1Neoplasm ProteinsPolymorphism, Single NucleotideRisk FactorsAntigens, NeoplasmGPI-Linked ProteinsMUC1 protein, humanMucin-1Neoplasm ProteinsPSCA protein, human

Identifiers

PMID42870271
PMCPMC13663241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.