Evidence map›Paper›PMID 42870248›Full record

ArticleBMC medical ethics2026

Moving the goal post and using ethics as a rhetorical refuge doesn't change the evidence: About the debate on the best care for minors with gender issues.

F D Zepf, M Ligges, C Ligges, L König, T Banaschewski, C S Monsalve, R Kaltiala, J Smids

Abstract readLetterComment
In one paragraph

Article in BMC medical ethics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

F D ZepfDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Am Steiger 6, Jena, 07743, Germany. florian.zepf@med.uni-jena.de.
M LiggesDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Am Steiger 6, Jena, 07743, Germany.
C LiggesDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Am Steiger 6, Jena, 07743, Germany.
L KönigDepartment of Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Am Steiger 6, Jena, 07743, Germany.
T BanaschewskiCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
C S MonsalveUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
R KaltialaDepartment of Adolescent Psychiatry, Tampere University Hospital, Tampere, Finland.
J SmidsDepartment of Public Health, Medical Ethics, Philosophy, and History of Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In their recent article, Oosthoek et al. propose a paradigm shift in the evaluation and justification of gender-affirming medical treatment (GAMT) for minors with gender dysphoria or gender incongruence. Rather than relying on traditional clinical outcome measures such as mental health, global functioning, or quality of life, they argue for a patient-defined standard centered around "embodiment goals" and autonomy. While we acknowledge the importance of incorporating patient perspectives and values, we raise significant theoretical and clinical concerns about the implications of this approach. Central to our critique is the tension between the authors' framework and established principles of medical ethics, especially beneficence and non-maleficence. We argue that abandoning the expectation of demonstrable clinical improvement undermines the professional ethos of health care and poses risks to vulnerable adolescents. Moreover, we caution against using ethics as a rhetorical refuge to justify treatments for which evidence of benefit remains weak or inconsistent. Instead of redefining effectiveness post hoc, we advocate for a robust evidence-based framework that prioritizes well-being and supports careful, honest shared decision-making. Non-medical interventions, including psychosocial support and treatment of comorbidities, should remain the first-line approach until stronger evidence for GAMT emerges. We call for improved research that evaluates both medical and non-medical interventions using established clinical outcome measures.

Indexed as

Ethics, MedicalGender DysphoriaGoalsMinorsAdolescentBeneficenceFemaleHumansMalePersonal AutonomyPuberty InhibitorsPuberty SuppressionQuality of LifePuberty InhibitorsChildren adolescentsCross-sex-hormonesDevelopment.EthicsGender dysphoriaGender incongruenceLife projectMinorsPuberty blockageSelf-interpretation

Identifiers

PMID42870248
PMCPMC13660275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.