ArticleBMC gastroenterology2026
Platelet P2Y12 inhibitor use and risk of colorectal cancer incidence and colorectal cancer-related mortality: a Swedish registry-based cohort study.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow-dose aspirin use is associated with reduced CRC incidence and CRC-related mortality. A similar association with P2Y12 inhibitor use remains uncertain. We investigated whether the use of P2Y12 inhibitors was associated with CRC incidence and CRC-related mortality among individuals diagnosed with atherosclerotic cardiovascular disease (ASCVD).
methodsFrom the ESPRESSO cohort, we identified 334,882 patients diagnosed with ASCVD between 2006 and 2021. We identified patients who initiated P2Y12 inhibitors ≥ 84 consecutive Defined Daily Doses (cDDDs). We estimated the risk of incident CRC and CRC mortality according to P2Y12 inhibitor use using Cox proportional-hazards regression models adjusting for potential confounders including comorbidities and regular aspirin use.
resultsWe documented 4,015 incident CRC cases and 2,610 CRC-related deaths during a median follow-up of 5.1 years (IRQ, 2.1-9.0 years). We did not observe an association between P2Y12 inhibitor use and CRC incidence. In contrast, a longer duration of P2Y12 inhibitor use was associated with lower CRC-related mortality. Compared to non-users, multivariable-adjusted hazard ratio (HR) for CRC mortality were 0.73 (95% CI, 0.60-0.89) in patients with 336-671 cDDDs of P2Y12 inhibitor and 0.81 (95% CI, 0.68-0.97) in those with ≥672 cDDDs. Among patients with incident CRC diagnosis, subsequent initiation of P2Y12 inhibitor after CRC diagnosis was associated with significantly lower CRC mortality (HR 0.42; 95% CI, 0.29-0.60).
conclusionsP2Y12 inhibitor use was not associated with risk of incident CRC but was significantly inversely associated with CRC mortality, which appeared to be due to improved survival among individuals who initiate P2Y12 inhibitors after CRC diagnosis. These findings merit further study given the observational nature of the analysis and potential for residual confounding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.