Evidence map›Paper›PMID 42870203›Full record

ArticleMolecular neurobiology2026

NAD+ Attenuates Neuroinflammation in Ischemic Stroke by Suppressing the cGAS- STING Pathway via Mitochondrial Homeostasis Restoration.

Sijia Jiang, Bo Liao, Guiping Wang, Rui Sheng, Chong Han, Zhi Jiang, ShanYao Pan, Chu Wu, Guoqiang Liang, Yongming Zhu and 16 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Sijia Jiang *Department of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703), Soochow University School of Pharmaceutical Science, Suzhou, 215123, China.
Bo Liao *School of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Guiping Wang *Laboratory Animal Center, Medical College of Soochow University, 199 Ren'ai Road, Suzhou, China.
Rui ShengDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703), Soochow University School of Pharmaceutical Science, Suzhou, 215123, China.
Chong HanSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Zhi JiangSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
ShanYao PanSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Chu WuSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Guoqiang LiangSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Yongming ZhuSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Ming ChengSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Feiyan ZhaoSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Zhiyin JiangSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Xuyi YaoSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Zhenghong QinInstitute of Health Technology, Suzhou Gaobo Vocational College, Suzhou High Technology District Science Town, 5 Qingshan Road, Suzhou, 215163, China.
Yaping HuaiDepartment of Rehabilitation Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, 518000, China.
Yiqing LuDepartment of Rehabilitation Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, 518000, China.
Weiwei YangDepartment of Rehabilitation Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, 518000, China.
Jie BaoSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Qing ZhangSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Gang ZhaoSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China.
Jiao DengDepartment of Rehabilitation Medicine, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, 213001, China.
Zhi Gang LvDepartment of Rehabilitation Medicine, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, 213001, China.
Junchao WuDepartment of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703), Soochow University School of Pharmaceutical Science, Suzhou, 215123, China.
Li LuoSchool of Physical Education and Sports Science, Soochow University, Suzhou, 215021, China. luoli@suda.edu.cn.
Yuanyuan QinSuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China. larvayy@163.com.

Funding

the Basic Research Project of Shenzhen Science, Technology and Innovation Commission JCYJ20240813152959014the National Natural Science Foundation of China 81301128the Natural Science Foundation of Nanjing University of Chinese Medicine XZR2023086the Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_3371the Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX25_3517the Science and Technology Development Plan of Suzhou SKYD2023156the Suzhou Health Youth Backbone Talent "National Tutorial System" Training Project Qngg2022024the Suzhou Hospital of Traditional Chinese Medicine Youth Research Project KY24007the Suzhou Science, Education, and Health Strengthening Project ZDXM2024012
6 · The paper itself

Abstract

Stroke remains one of the leading causes of death and disability worldwide, with neuroinflammation playing a critical role in its pathogenesis. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a major driver of innate immune responses activated by endogenous DNA, including mitochondrial DNA (mtDNA), and contributes significantly to post-ischemic neuroinflammation. Nicotinamide adenine dinucleotide (NAD

Indexed as

HomeostasisIschemic StrokeMembrane ProteinsMitochondriaNADNeuroinflammatory DiseasesNucleotidyltransferasesAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLMicrogliaProtein Serine-Threonine KinasescGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNADNucleotidyltransferasesProtein Serine-Threonine KinasesSting1 protein, mouseSTING ProteinCGAS-STING pathwayIschemic strokeMicrogliaMitochondrial homeostasisNAD+Neuroinflammation

Identifiers

PMID42870203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.