Evidence map›Paper›PMID 42870093›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2027

Molecular Recognition Force Spectroscopy for Probing Cell-Targeted Nanoparticles In Vitro.

Carla P Gomes, Hugo Oliveira, Andreas Ebner, Peter Hinterdorfer, Ana P Pêgo

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carla P GomesInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Hugo OliveiraUniversity of Bordeaux, Tissue Bioengineering, U1026, F-33076 Bordeaux, France; Inserm, Tissue Bioengineering, U1026, F-33076, Bordeaux, France.
Andreas EbnerInstitute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Peter HinterdorferInstitute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Ana P PêgoInstituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal. apego@i3s.up.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the development and design of cell-targeted nanoparticle-based systems, the density of targeting moieties plays a fundamental role in allowing maximal cell-specific interaction. Here, we describe the use of molecular recognition force spectroscopy as a valuable tool for the screening, characterization, and optimization of targeted nanoparticles toward attaining cell-specific interaction. By tailoring the density of targeting moieties at the nanoparticle surface, one can correlate the unbinding event probability between nanoparticles tethered to an atomic force microscopy tip and cells to the nanoparticle vectoring capacity. This approach allows for a rapid and cost-effective design of targeted nanomedicines, reducing the need for long and tedious in vitro tests.

Indexed as

Drug Delivery SystemsMicroscopy, Atomic ForceNanoparticlesHumansNanomedicineDrug deliverySingle molecule force spectroscopyTailored nanomedicineTargeted nanoparticlesTip functionalization

Identifiers

PMID42870093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.