ReviewJournal of neural transmission (Vienna, Austria : 1996)2026
The role of transcranial direct current stimulaton on ataxia: a scoping review.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebellar ataxias are a diverse group of hereditary and acquired disorders that impair balance, gait, posture and ocular movements. With limited treatment options, particularly in hereditary forms, neuromodulation has emerged as a promising therapeutic approach particularly the transcranial direct current stimulation (tDCS). This scoping review aims to discuss the role of tDCS as a potential therapy in reducing ataxia symptoms in both hereditary and acquired forms. A total of 787 studies were found after searching Pubmed, EMBASE, and Cochrane. After removing 273 duplicates, 514 studies remained for title and abstract screening. Of these, 387 studies were excluded, leaving 127 studies for full-text assessment. Following retrieval of full text, 26 was assessed for eligibility. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A comprehensive literature search was performed using PubMed, EMBASE, and Cochrane databases. Two independent reviewers screened studies through title/abstract and full-text review, with disagreements resolved by discussion or adjudication by two additional reviewers when necessary. We included 18 studies for the final analysis. Most studies reviewed showed that tDCS is a potential option for the treatment of ataxia, however, differences among participants, neuromodulation techniques, or trial protocols may have led to differences in the clinical outcomes. Our review highlights that the vast majority of the randomized controlled studies of tDCS in neurodegenerative ataxias have demonstrated clinical beneficial effect. There are preliminary observations that tDCS in combination therapy with rehabilitation or exercise may provide greater or more functional improvements. Future multicenter studies with long term follow up of individual disease groups, supported by clinical, imaging and biological marker measurements will help address the current limitations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.