ArticleCardiovascular and interventional radiology2026
Endovascular Therapy for Femoropopliteal Artery Lesions Involving the Popliteal Artery: 1-Year Outcomes from a Real-World Multicenter Registry.
Article in Cardiovascular and interventional radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04826705 (A Prospective, Multicenter, Observational Study of Short and Long-term Outcome in Endovascular Treatment of Femoropopliteal Arterial Occlusive Lesion With Drug-Coated Balloon), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Multicenter, Observational Study of Short and Long-term Outcome in Endovascular Treatment of Femoropopliteal Arterial Occlusive Lesion With Drug-Coated Balloon (PROMISING Study)
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Authors and funding
10 authors.
Funding
Abstract
purposeTo evaluate real-world outcomes of endovascular treatment for femoropopliteal lesions involving the popliteal artery and, in a post-hoc exploratory analysis, assess whether anatomical location (P3 vs. P1/P2 segments) was associated with clinical decision-making and prognosis. MATERIALS AND
methodsWe conducted a retrospective, post-hoc analysis of 946 patients from the prospective PROMISING registry. For this exploratory analysis, patients were stratified according to distal (P3) versus proximal/mid (P1/P2) popliteal artery involvement. Predictors of stent implantation and clinical decision pathways were compared across groups.
resultsOverall procedural success was 98.5%, and the 12-month freedom from major adverse events (MAE), defined as a composite of all-cause mortality, major amputation, or clinically driven target lesion revascularization, was 80.1%. Multivariable analysis indicated P3 involvement independently predicted reduced stent implantation (OR 0.66, 95% CI 0.46-0.95, p = 0.027). For vessel preparation, the P3 group more frequently utilized plain old balloon angioplasty (POBA, 67.8% vs. 54.8%, p < 0.001) rather than directional atherectomy or specialty balloons. Despite a lower stent implantation rate and greater use of POBA, 12-month freedom from MAE was comparable between the P3 and P1/P2 groups (78.0% vs. 81.2%, p = 0.481).
conclusionIn this post-hoc analysis of real-world registry data, popliteal lesion location was associated with differences in operator treatment strategies. P3 involvement was associated with less frequent stent implantation and greater use of plain balloon angioplasty, while 1-year clinical outcomes were comparable between the P3 and P1/P2 groups. These exploratory findings require external validation before they can be used to inform clinical treatment strategies.
trial registrationClinicalTrials.gov identifier NCT04826705 (Registered on March 29, 2021).
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