Evidence map›Paper›PMID 42869935›Full record

ReviewNPJ Parkinson's disease2026

Perspectives on ionizing radiation and Parkinson's disease.

Kathleen B Miller, Nilufar Ali, Mandi Beavers, Steve Blattnig, John D Boice, Egle Cekanaviciute, Sylvain V Costes, Lawrence T Dauer, Gregory Nelson, M Kerry O'Banion and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kathleen B MillerDepartment of Health and Exercise Science, University of St. Thomas, Saint Paul, MN, USA. mill4945@stthomas.edu.
Nilufar AliDepartment of Biological Sciences, Boise State University, Boise, ID, USA.
Mandi BeaversTulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Steve BlattnigNASA Langley Research Center, Hampton, VA, USA.
John D BoiceVanderbilt University School of Medicine, Nashville, TN, USA.
Egle CekanaviciuteSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Sylvain V CostesDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Lawrence T DauerDepartments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Gregory NelsonDepartments of Basic Sciences and Radiation Medicine, Loma Linda University, Loma Linda, CA, USA.
M Kerry O'BanionDepartment of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Sergey Y TolmachevUnited States Transuranium and Uranium Registries, Washington State University, Richland, WA, USA.
Catherine DavisDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Diego IaconoDepartments of Neurology, Pathology and Neuroscience, DoD/USU Brain Tissue Repository & Neuropathology Program, Uniformed Services University (USU), The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence from terrestrial cohorts suggests that ionizing radiation (IR) exposure may increase the risk of Parkinson's disease (PD). Understanding the biological mechanisms underlying IR-induced PD is therefore critical for assessing health risks, particularly in the context of long-duration missions to the Moon and Mars. This perspective explores mechanistic pathways that may support causal links between IR and PD and highlights experimental and epidemiological approaches relevant for strengthening causal inference.

Identifiers

PMID42869935
PMCPMC13661608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.