ArticleNature communications2026
The 11-hydroxy-jasmonic acid pathway expands jasmonate catabolic repertoire for stress-specific hormone attenuation in Arabidopsis.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The plant hormone jasmonoyl-isoleucine (JA-Ile) reallocates resources from growth towards induced defenses upon microbial or herbivore attacks or other environmental threats. JA-Ile and its precursor jasmonic acid (JA) undergo complex enzymatic turnover that shape hormonal dynamics for optimal signaling. JA-Ile is inactivated through gradual oxidation by CYP94 monooxygenases, followed by 12-OH-JA-Ile deconjugation towards 12-OH-JA. 12-OH-JA was believed to originate also from direct JA hydroxylation by JAO/JOX dioxygenases. Here we investigate the nature and origins of hydroxy-JAs and their derivatives upon stress responses in Arabidopsis. Using a set of analytical methods to explore enzyme assays and multiple pathway-impaired mutants, we show that JAO enzymes produce exclusively 11-OH-JA rather than 12-OH-JA and define a separate branch in JA catabolism. Upon leaf wounding, the CYP94/AH and, to a lesser extent, the JAO pathways direct the respective accumulation of 12- and 11-OH-JAs and their 11/12-glucosylated and 12-sulfated derivatives with isoform-specific occurrences. In contrast, Botrytis infection triggers the exclusive accumulation of 11-OH-JA and 11-Glc-O-JA with complex patterns of HSO
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