Evidence map›Paper›PMID 42869916›Full record

ArticleNature communications2026

CD200

Mario R Angeli, Christian Schütz, Hashem Schmidt, Richard Demmler, Jiyang Chang, Hannah Labinsky, Maria Gabriella Raimondo, Brikena Lalazi, Katerina Stergioula, Kaiyue Huang and 15 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Mario R AngeliDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0002-2911-4269
Christian SchützRuhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany.ORCID http://orcid.org/0000-0002-2361-2785
Hashem SchmidtDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Richard DemmlerDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0009-0004-3476-2481
Jiyang ChangDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Hannah LabinskyDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Maria Gabriella RaimondoDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0003-2020-6711
Brikena LalaziRuhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany.
Katerina StergioulaDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Kaiyue HuangDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Vladyslav FedorchenkoDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Mohan LiDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Zoltán WinterInstitute of Radiology, University Hospital, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0003-4119-9637
Styliani TsiamiRuhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany.
Arnd LienertCenter for Orthopedics and Traumatology, St. Anna Hospital, Herne, Germany.
Sebastian RüttenCenter for Orthopedics and Traumatology, St. Anna Hospital, Herne, Germany.
Stefanie WeberDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Markus LuberDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0003-1895-5481
Tobias BäuerleInstitute of Radiology, University Hospital, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Reza BahramiDepartment for Spinal Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.ORCID http://orcid.org/0009-0005-6299-5546
Heinrich BoehmDepartment for Spinal Surgery, Zentralklinik Bad Berka, Bad Berka, Germany.
Georg SchettDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0001-8740-9615
Simon RauberDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.ORCID http://orcid.org/0000-0001-8306-9334
Xenofon Baraliakos *Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Herne, Germany.
Andreas Ramming *Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. andreas.ramming@uk-erlangen.de.ORCID http://orcid.org/0000-0002-7003-501X

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01EC1903ADeutsche Forschungsgemeinschaft (German Research Foundation) 423477573, 493624887, 501752319, 550296805Deutsche Forschungsgemeinschaft (German Research Foundation) 456565718Deutsche Forschungsgemeinschaft (German Research Foundation) 493624887, 550296805Deutsche Forschungsgemeinschaft (German Research Foundation) 501752319, 550296805, Gottfried Wilhelm Leibniz Prize 2023Deutsche Forschungsgemeinschaft (German Research Foundation) 550296805, 568819271EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 810316EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 853508Innovative Medicines Initiative (IMI) 101007757, 777357
6 · The paper itself

Abstract

Granulocytic myeloid-derived suppressor cells (G-MDSCs) are immunoregulatory cells of the neutrophil lineage. Here, we show that immunoregulation by G-MDSCs is imprinted by the joint tissue microenvironment in patients with axial spondyloarthritis and in animal models of inflammatory arthritis. We demonstrate that the suppressive function of G-MDSCs is significantly enhanced in the joint tissue, but not in the circulation. Analysis of public single-cell RNA sequencing datasets was consistent with Cd200r1

Indexed as

Antigens, CDArthritisArthritis, ExperimentalFibroblastsMyeloid-Derived Suppressor CellsAdoptive TransferAnimalsB7-H1 AntigenCell DifferentiationFemaleGranulocytesHumansInflammationMaleMiceMice, Inbred C57BLAntigens, CDantigens, CD200B7-H1 AntigenCD200R1 protein, humanCd200r1 protein, mouseOrexin Receptors

Identifiers

PMID42869916
PMCPMC13661617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.