Evidence map›Paper›PMID 42869912›Full record

ArticleNature communications2026

Tumor-targeted IL-10 synergizes with IL-2 to enhance antitumor immunity while minimizing immune-related adverse events.

Zhichen Sun, Yifei Hu, Casey Moore, Baran D Sumer, Tao Wang, Jian Qiao

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhichen SunDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-7837-8407
Yifei HuQuantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0009-0005-5709-4129
Casey MooreDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Baran D SumerDepartment of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-8371-4388
Tao WangDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4355-149X
Jian QiaoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Jian.Qiao@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-5228-2906

Funding

Project 3U54CA244719 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, ZHIJIAN J · 2019 to 2019
$5.2M
A pH Responsive Transistor-like Nanoprobe for Sensitive Detection of Unknown Primary Cancers of the Head and NeckR01CA266146 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Baran D Sumer · 2022 to 2026
$2.8M
Machine learning for identifying antigen-antibody interactions from massive sequencing dataR01AI190103 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Junzhou Huang, JUN WANG · 2025 to 2026
$1.3M
TCR-antigen foundation model to empower TCR-based diagnostics and therapeuticsR01AI192499 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI David Eric Gerber, Jian Qiao · 2025 to 2026
$1.0M
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP230363 to T.W.NCI NIH HHS R01 CA266146NCI NIH HHS U54 CA244719NIAID NIH HHS R01 AI190103NIAID NIH HHS R01 AI192499U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA266146 to B.D.S.U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U54CA244719 to B.D.SU.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U54CA244719 to J.Q.U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI190103 to T.W.U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI192499 to J.Q.U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI192499 to T.W.
6 · The paper itself

Abstract

Tumor-targeting cytokines have emerged as a promising strategy for cancer immunotherapy, although their mechanisms of action often remain complex. In this study, we develop an approach by combining tumor-targeted IL-10 (CmAb-(IL10)

Indexed as

Interleukin-10Interleukin-2NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsDrug SynergismFemaleHumansImmunotherapyMiceReceptors, Interleukin-10Interleukin-10Interleukin-2Receptors, Interleukin-10

Identifiers

PMID42869912
PMCPMC13661516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.