ArticleNature communications2026
CG14075/Mmt promotes amino acid catabolism and cooperates with AKH during starvation in Drosophila.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Starvation triggers the sequential mobilization of glycogen, lipids, and amino acids to sustain survival, yet the hormonal mechanisms coordinating these transitions remain poorly understood. Here, we identify CG14075/Marmite (Mmt) as a hormone-like peptide secreted from the corpora cardiaca (CC) of Drosophila melanogaster during prolonged nutrient deprivation. CG14075/Mmt is progressively released into the haemolymph during starvation, coinciding with the decline of glycogen and lipid stores. CG14075/Mmt contributes to the regulation of amino acid catabolism, with prominent effects on threonine and branched-chain amino acid metabolism, and its absence leads to amino acid accumulation associated with oxidative stress. Moreover, CG14075/Mmt functions alongside adipokinetic hormone (AKH), the lipid-catabolic glucagon-like hormone, to regulate lipid and amino acid metabolism during starvation. Loss of CG14075/Mmt accelerates lipid and glycogen consumption and reduces starvation resistance, phenotypes that are partly associated with increased AKH secretion. These findings reveal a CC-derived endocrine component that contributes to the coordinated utilization of multiple energy substrates during nutrient stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.