Evidence map›Paper›PMID 42869892›Full record

ArticleNature communications2026

Hos2-mediated KatG1 decrotonylation orchestrates ROS scavenging in rice blast infection.

Zhiyong Ren, Zhirong Peng, Yong Zhang, Shanjun Tang, Shikun Xiang, Jun Zhu, Xiang Dong, Mengxi Tang, Shimei Zhang, Mengyuan Qin and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Zhiyong Ren *State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China.
Zhirong Peng *State Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China.
Yong ZhangHunan Institute of Nuclear Agriculture Sciences and Chinese Herbal Medicines, Changsha, China.
Shanjun TangState Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China.
Shikun XiangState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Jun ZhuState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xiang DongState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Mengxi TangState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Shimei ZhangState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Mengyuan QinState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Zhiguang QuState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Yanling KongState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.
Junjie XingState Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China.
Jingbo XuState Key Laboratory of Hybrid Rice, Hunan Hybrid Rice Research Center, Changsha, China. chenxiaolin@mail.hzau.edu.cn.
Xiao-Lin ChenState Key Laboratory of Agricultural Microbiology and Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China. jb68@263.net.ORCID http://orcid.org/0000-0002-5492-516X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In plant-pathogen interaction, plants trigger reactive oxygen species (ROS) bursts to defend against pathogen invasion, while pathogens evolved antioxidant systems to scavenge ROS for infection. Our study reveals a regulatory mechanism of ROS adaptation and scavenging in the rice blast fungus Magnaporthe oryzae. We found that KatG1, a bifunctional catalase-peroxidase, acts as a ROS-responsive regulatory enzyme. During infection, the deacetylase Hos2 mediates the decrotonylation of KatG1 at K422, initiating the ROS clearance process. Decrotonylated KatG1 depolymerizes into monomers, interacts with the Hsp70 protein Ssb1, and translocates to the nucleus. Nuclear KatG1 promotes the dissociation of the Atf1-Tup1 complex, activating the expression of Atf1-mediated oxidoreductase genes and enhancing fungal infection. Moreover, we identified a small molecule, orcinol gentiobioside (OGB), that targets KatG1, inhibiting M. oryzae invasion. This study elucidates a regulatory mechanism of ROS metabolism and stress adaptation in plant fungal infections and provides a potential target for fungicide development to control rice blast disease.

Indexed as

AscomycotaCatalaseFungal ProteinsOryzaPlant DiseasesReactive Oxygen SpeciesHost-Pathogen InteractionsMagnaportheCatalaseFungal ProteinsReactive Oxygen Species

Identifiers

PMID42869892
PMCPMC13662202

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