Evidence map›Paper›PMID 42869850›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory.

Quentin Devignes, Patrick J Pruitt, Kenneth Petscavage, Robert A Koeppe, Roger L Albin, Scott J Peltier, Annalise Rahman-Filipiak, Bruno Giordani, Alexandru D Iordan, Benjamin M Hampstead

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Quentin DevignesResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-7544-6328
Patrick J PruittResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Kenneth PetscavageResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Scott J PeltierFunctional MRI Laboratory, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Annalise Rahman-FilipiakResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Bruno GiordaniResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Alexandru D IordanResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Benjamin M HampsteadResearch Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOUGLAS C NOLL · 2021 to 2026
$26.5M
Treating mild cognitive impairment with transcranial direct current stimulationR01AG058724 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2018 to 2022
$8.4M
Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
Biograph Vision 600 PET/CT systemS10OD034250 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT, PETER JAMES HENRY · 2023 to 2023
$2.0M
NCATS NIH HHS UM1 TR004404NCATS NIH HHS UM1TR004404NIA NIH HHS P30 AG072931NIA NIH HHS P30AG072931NIA NIH HHS R01 AG058724NIA NIH HHS R01AG058724NIA NIH HHS R35 AG072262NIA NIH HHS R35AG072262NIH HHS S10 OD034250NIH Office of the Director S10OD034250
6 · The paper itself

Abstract

introductionWe examined how amyloid beta (Aβ) and tau accumulation affected gray matter (GM) microstructural integrity and how such alterations impacted memory.

methodsWe tested voxel-wise mediation models to examine the relationships between (1) positron emission tomography-derived Aβ and tau accumulation and GM microstructural integrity assessed with neurite orientation dispersion and density imaging, (2) GM microstructural integrity and memory controlling for Aβ and tau, and (3) the indirect effect of Aβ and tau on memory through GM microstructural integrity in 194 participants with memory impairments.

resultsTau had a greater impact on GM microstructure than did Aβ. GM microstructural alterations in posterior cortical regions were associated with worse memory when controlling for Alzheimer's proteinopathies. GM microstructural alterations mediated the relationship between Alzheimer's proteinopathies and memory. DISCUSSION: GM microstructural alterations have functional ramifications given their mediating effect on the relationship between Alzheimer's proteinopathies and memory and their association with worse memory beyond Alzheimer's proteinopathies.

Indexed as

Alzheimer DiseaseBrainGray MatterMemory DisordersAgedAged, 80 and overAmyloid beta-PeptidesFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsPositron-Emission Tomographytau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer's diseaseamyloidmemoryneurite orientation dispersion and density imagingpositron emission tomographytau

Identifiers

PMID42869850
PMCPMC13661745

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.