ArticleBMJ open2026
Can metformin prolong pregnancy in preterm pre-eclampsia? Study protocol for a Nordic multicentre randomised placebo-controlled trial (PI4).
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Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
39 authors.
Pia GudmundssonDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.
Catherine Anne CluverSAMRC Preeclampsia Extramural Research Unit, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-0406-8964
Anna SandströmClinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2879-4271
Linda LindströmDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Simon TimpkaPerinatal and Cardiovascular Epidemiology, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Susanne HesselmanDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Caroline LilliecreutzClinical Department of Obstetrics and Gynaecology, Linköping University Hospital, Linköping, Sweden.
Sophia Brismar WendelDepartment of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-9401-8062
Emma Von WowernDepartment of Obstetrics and Gynaecology, Skåne University Hospital Lund, Lund, Sweden.ORCID http://orcid.org/0000-0001-6239-2693
Karolina LindenInstitute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2792-3142
Ola AnderssonDepartment of Clinical Sciences, Lund, Paediatrics, Lund University Faculty of Medicine, Lund, Sweden.ORCID http://orcid.org/0000-0002-3972-0457
Hanna GyllenstenInstitute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-6890-5162
Mårten AlkmarkDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.
Emma NorrmanDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.
Erica WesslénDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.
Angla MantelClinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Marie BlombergClinical Department of Obstetrics and Gynaecology, Linköping University Hospital, Linköping, Sweden.
Hugo AronzonDepartment of Women's Health, Danderyd Hospital, Stockholm, Sweden.
Hannele LaivuoriFaculty of Medicine and Health Technology, Centre for Child, Adolescent, and Maternal Health Research, Tampere Universities, Tampere, Pirkanmaa, Finland.ORCID http://orcid.org/0000-0003-3212-7826
Pia VillaDepartment of Obstetrics and Gynaecology, Helsinki University Hospital and University of Helsinki, HUS Helsinki University Hospital, Helsinki, Uusimaa, Finland.
Trond Melbye MichelsenDepartment of Obstetrics, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-9534-6255
Ingvil Krarup SørbyeDepartment of Obstetrics, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-8998-4285
Camilla HaavaldsenDepartment of Obstetrics and Gynaecology, Akershus University Hospital, Lørenskog, Norway.
Marie-Therese VinnarsDepartment of Clinical Sciences, Obstetrics and Gynaecology, Umeå University, Umeå, Sweden.
Eleonor TibladClinical Epidemiology Division, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Nadine RaabDepartment of Obstetrics and Gynaecology, Norrland University Hospital, Umeå, Västerbotten County, Sweden.
Elli ToivonenFaculty of Medicine and Health Technology, Centre for Child, Adolescent, and Maternal Health Research, Tampere Universities, Tampere, Pirkanmaa, Finland.ORCID http://orcid.org/0000-0001-5637-3445
Ann HellströmDepartment of Clinical Neuroscience, University of Gothenburg Institute of Neuroscience and Physiology, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9259-1244
Karin SävmanDepartment of Paediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Hanna OhlssonDepartment of Paediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Stina BerverDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.
Emelie OttossonDepartment of Obstetrics and Gynaecology, Skaraborg Hospital Skövde, Skövde, Sweden.
Carina BejlumDepartment of Obstetrics and Gynaecology, Norra Älvsborg County Hospital, Trollhättan, Sweden.
Merit KullingerDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Karin StenfeldtPreeclampsia Patient Organization, Lund, Sweden.
Susan P WalkerDepartment of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, The University of Melbourne Melbourne Medical School, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9075-4655
Stephen TongDepartment of Obstetrics, Gynaecology and Newborn Health, Mercy Hospital for Women, The University of Melbourne Melbourne Medical School, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-2319-0586
Henrik ImbergDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-9447-663X
Lina BergmanDepartment of Obstetrics and Gynaecology, University of Gothenburg, Gothenburg, Sweden Lina.bergman@obgyn.gu.se.ORCID http://orcid.org/0000-0001-5202-9428
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Fetal medicineMaternal medicinePregnancyRandomized Controlled Trial
Identifiers
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Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.