Evidence map›Paper›PMID 42869472›Full record

ArticleProceedings. Biological sciences2026

Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.

Jiahuan Liu, Andy Kraja, Samantha N Davis, Hannah Gelnaw, Naoroz Mahmood, David Schoppik, Yunlu Zhu

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiahuan LiuDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0000-0002-9567-0757
Andy KrajaCourant Institute of Mathematical Sciences, New York University , New York, NY, USA.ORCID 0009-0001-6112-9356
Samantha N DavisDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0000-0003-2704-9480
Hannah GelnawDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0000-0002-7970-796X
Naoroz MahmoodDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0009-0008-5182-0486
David SchoppikDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0000-0001-7969-9632
Yunlu ZhuDepartments of Neuroscience, Otolaryngology, and the Institute for Translational Neuroscience, NYU Grossman School of Medicine , New York, NY, USA.ORCID 0000-0003-2474-2714

Funding

Functional maturation of interneurons that mediate the vestibulo-ocular reflex - Renewal - Resubmission - 1R01DC017489 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI David Schoppik · 2019 to 2026
$4.8M
A Phenotype-Optimized Zebrafish Model of Progressive Supranuclear PalsyR33NS125280 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BURTON, EDWARD ALAN, SCHOPPIK, DAVID · 2023 to 2024
$531k
National Institute on Deafness and Communication Disorders of the National Institutes of Health R01DC017489NIDCD NIH HHS R01 DC017489NINDS NIH HHS R33 NS125280NINDS NIH HHS R33NS125280Rainwater Charitable Foundation
6 · The paper itself

Abstract

Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strategies that larval zebrafish (Danio rerio) use to control posture and navigate the water column in response to light and circadian cues. In the dark, larvae maintain balance by swimming in long bouts with large nose-up rotations, compensating for nose-down drift accrued during prolonged inactivity. Effective postural compensation requires vestibular sensation from the utricle. By contrast, in the light, larvae navigate with short, frequent and variable bouts. While lighting exerts a dominant, masking effect on the locomotor strategies, circadian rhythms modulate swim kinematics. Our results reveal distinct light-dark locomotor strategies and disentangle how ambient light and the internal clock jointly shape balance control and navigation. This work lays the foundation for understanding how external and internal cues interact to govern locomotor activity in freely moving diurnal animals.

Indexed as

Circadian RhythmPostural BalanceZebrafishAnimalsBiomechanical PhenomenaCuesLarvaLightLightingLocomotionSwimmingbiological clockcircadianlocomotionmotor behaviourpostural controlvestibular systemzebrafish

Identifiers

PMID42869472
PMCPMC13678715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.