Evidence map›Paper›PMID 42869233›Full record

ArticleInternational journal of antimicrobial agents2026

Vancomycin Population Pharmacokinetics and Exposure Variability in Children with Multiple Organ Dysfunction Syndrome.

Marc H Scheetz, Justin Shiau, Victor Amajor, Amanda Bwint, Anna Sharova, Josey Hensley, Steven L Shein, Janet R Hume, Courtney M Rowan, Carolina Quintana Grijalba and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of antimicrobial agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Marc H ScheetzPharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL. Electronic address: mschee@midwestern.edu.
Justin ShiauPharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL.
Victor AmajorDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.
Amanda BwintDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.
Anna SharovaDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.
Josey HensleyDivision of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH.
Steven L SheinDivision of Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH.
Janet R HumeDivision of Critical Care Medicine, University of Minnesota Masonic Children's Hospital, Minneapolis, MN.
Courtney M RowanDivision of Critical Care Medicine, Indiana University School of Medicine at Riley Children's Health, Indianapolis, IN.
Carolina Quintana GrijalbaDivision of Critical Care Medicine, Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA.
Matthew P MaloneDepartment of Pediatrics, Division of Critical Care Medicine, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR.
Erin K StensonDivision of Critical Care Medicine, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO.
Scott L WeissDivision of Critical Care Medicine, Department of Pediatrics, Nemours Children's Hospital, Wilmington, DE and Departments of Pediatrics and Pathology & Genomic Medicine, Sidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, PA.
Matt S ZinterDivision of Critical Care Medicine, University of California-San Francisco Benioff Children's Hospitals, San Francisco, CA.
Sujatha KannanDivision of Pediatric Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Mary K DahmerDivision of Pediatric Critical Care Medicine, University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI.
Ryan NofzigerDivision of Critical Care Medicine, Akron Children's Hospital, Akron, OH.
Nathaniel J RhodesPharmacometrics Center of Excellence, Midwestern University, Downers Grove, IL.
Athena F ZuppaDepartment of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia PA.
Manjunath P PaiPK Core Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI.
Mark W HallDivision of Critical Care Medicine, Nationwide Children's Hospital, Columbus, OH.
Kevin J DownesDivision of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia PA.
PALISI Network Investigators

Funding

Assessment of MODS and Personalized Exposures of AntibioticsR01HD103755 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI DOWNES, KEVIN JAMES, SCHEETZ, MARC HOWARD · 2021 to 2025
$3.7M
PediAtric ReseArch of Drugs, Immunoparalysis and Genetics during MODS (PARADIGM)R01HD095976 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2019 to 2023
$3.4M
NICHD NIH HHS R01 HD095976NICHD NIH HHS R01 HD103755
6 · The paper itself

Abstract

In children with multiple organ dysfunction syndrome (MODS), vancomycin dosing is frequently guided by population-based approaches followed by therapeutic drug monitoring that requires considerable blood volumes. We sought to develop a population pharmacokinetic (PK) model and describe vancomycin exposures using blood-sparing, whole-blood volumetric absorptive microsampling (VAMS). In this multicentre prospective observational study, up to 15 PK samples were collected per subject over 3 days. Individual whole-blood areas under the concentration-time curve during 0-24 hours (AUC

Indexed as

Multiple Organ Dysfunction SyndromePediatricPK/PDvancomycinVolumetric Absorptive Microsampling (VAMS)

Identifiers

PMID42869233
PMCPMC13690187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.