Evidence map›Paper›PMID 42868989›Full record

ArticleStem cell reports2026

Photoreceptor replacement therapy using a tissue scaffold shows evidence of donor-host integration in non-human primate retina.

Laura Patak, Soumaya Belhadj, Agustin Luz-Madrigal, Praveen Joseph Susaimanickam, Jennifer M LaPorta, Tsung-Han Tsai, Ruosen Xie, Jacqueline Gayet, Hector C Baez, William S Fischer and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Laura PatakVision Science Graduate Group, Herbert Wertheim School of Optometry & Vision Science & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Soumaya BelhadjCenter for Visual Science, University of Rochester, Rochester, NY, USA.
Agustin Luz-MadrigalWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Praveen Joseph SusaimanickamWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
Jennifer M LaPortaCenter for Visual Science, University of Rochester, Rochester, NY, USA.
Tsung-Han TsaiDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Ruosen XieMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.
Jacqueline GayetVision Science Graduate Group, Herbert Wertheim School of Optometry & Vision Science & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Hector C BaezCenter for Visual Science, University of Rochester, Rochester, NY, USA; University of Rochester Hajim School of Engineering and Applied Sciences, Rochester, NY, USA.
William S FischerCenter for Visual Science, University of Rochester, Rochester, NY, USA.
Rachel HollarCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA.
Nathaniel FoleyCenter for Visual Science, University of Rochester, Rochester, NY, USA; Vision Science Graduate Group, Herbert Wertheim School of Optometry & Vision Science & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Andrea L CampbellCenter for Visual Science, University of Rochester, Rochester, NY, USA.
Shaoqin GongMcPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.
Zhenqiang MaDepartment of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Arvydas MaminishkisNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Kapil BhartiNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Juan AmaralNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Vamsi K GullapalliFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA.
David A DiLoretoFlaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA.
David M GammWaisman Center, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Teresa PuthusseryVision Science Graduate Group, Herbert Wertheim School of Optometry & Vision Science & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: tputhussery@berkeley.edu.
Juliette E McGregorCenter for Visual Science, University of Rochester, Rochester, NY, USA; Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: jmcgrego@ur.rochester.edu.

Funding

VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI MICHELE RUCCI · 1985 to 2026
$17.5M
VISUAL SCIENCET32EY007125 · NEI · UNIVERSITY OF ROCHESTER · PI Krystel R Huxlin, Duje Tadin · 1990 to 2026
$7.1M
Supplement to Accelerating photoreceptor replacement therapy with in-vivo cellular imaging of retinal functionU24EY033275 · NEI · UNIVERSITY OF ROCHESTER · PI MCGREGOR, JULIETTE ELIZABETH · 2021 to 2025
$5.7M
NEI NIH HHS P30 EY001319NEI NIH HHS T32 EY007125NEI NIH HHS U24 EY033275
6 · The paper itself

Abstract

Retinal degeneration is characterized by progressive photoreceptor (PR) loss, leading to visual impairment and ultimately blindness. PR replacement is a promising therapeutic strategy, but surgical delivery remains challenging, and efficacy in primates remains unknown. Tissue scaffolds hold potential for better control over cell delivery and distribution. Here, we delivered a scaffold, loaded with human embryonic stem-cell-derived PR precursors (PRPs), to the subretinal space of a non-human primate (NHP) and monitored donor PR survival and morphology in vivo. A substantial fraction of donor PRs survived for 20-weeks, with neurite extension by week 7 and some morphological elongation by week 17. Immunolabeling confirmed donor PR survival at 20 weeks with expression of key phototransduction and ribbon proteins, and some donor PRs forming putative synapses with host bipolar cells (BCs), including midget BCs. These findings suggest that scaffold-mediated PR replacement holds promise for restoring high acuity foveal vision.

Indexed as

Photoreceptor Cells, VertebrateRetinaRetinal DegenerationTissue ScaffoldsAnimalsHumansRetinal Bipolar CellsAOSLObipolar cell remodellingfoveahost-graft synapsesmacular degenerationregenerative therapyretinal imagingretinal plasticitytransplantationvision restoration

Identifiers

PMID42868989
PMCPMC13681418

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.