Evidence map›Paper›PMID 42868976›Full record

ArticleJACC. Basic to translational science2026

A Circulating Extracellular Vesicle-Bound Fraction of Cardiac Troponin Discriminates Myocardial Homeostasis and Disease States.

Jona Benjamin Krohn, Dominika Bernath-Nagy, Yuetong Leona Ding, Melek Sükran Kalinyaprak, Liliana Francois, Gabriel Jakob Trauner, Chiara Hess, Niklas Hartmann, Felix Wiedmann, Constanze Schmidt and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jona Benjamin KrohnDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Dominika Bernath-NagyDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
Yuetong Leona DingDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany.
Melek Sükran KalinyaprakDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany.
Liliana FrancoisDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Gabriel Jakob TraunerDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany.
Chiara HessDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany.
Niklas HartmannDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Felix WiedmannDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany; Department of Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Lower Saxony, University of Goettingen, Goettingen, Germany.
Constanze SchmidtDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany; Department of Cardiology and Pneumology, University Medical Center Goettingen, Goettingen, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Lower Saxony, University of Goettingen, Goettingen, Germany.
Hugo KatusDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Norbert FreyDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Florian LeuschnerDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) Partner Site Heidelberg/Mannheim, University of Heidelberg, Heidelberg, Germany.
Evangelos GiannitsisDepartment of Cardiology, Pulmonology and Angiology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address: evangelos.giannitsis@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient troponin elevation is a common observation in various nonischemic cardiovascular diseases, the origin of which remains widely unknown. We hypothesized that troponins enclosed in extracellular vesicles (EVs) and released by cardiomyocytes into circulation account for distinct disease-specific compartmental troponin signatures. In vitro, hypoxic cardiomyocytes secreted EVs enriched with cardiac troponin T (cTnT). Mice after myocardial infarction showed increased blood EV concentration, and pigs under induced atrial fibrillation showed distinct EV-cTnT signatures. These specific EV-cTnT and cardiac troponin I compartmental patterns were verified in 2 patient cohorts of myocardial infarction and atrial fibrillation, introducing relative EV-cardiac troponin as a novel biomarker to discriminate cardiovascular pathologies.

Indexed as

biomarker discoverycardiac troponinsextracellular vesiclesmyocardial injurymyocardial ischemia

Identifiers

PMID42868976
PMCPMC13685000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.