Evidence map›Paper›PMID 42868206›Full record

ArticlePLoS pathogens2026

MicroRNA-1246 regulates macrophage lipid metabolism and is involved in resistance to human Mycobacterium tuberculosis infection.

Ashutosh Tripathi, Venkata Sanjeev Kumar Neela, Rajesh Kumar Radhakrishnan, Kamakshi Prudhula Devalraju, Anvesh Kumar Bogam, Tanmoy Mukherjee, Varalakshmi Mallidi, Abhinav Vankayalapati, Mohammed Soheb Sadath Ansari, Carlos Arana and 5 more

Abstract read
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In one paragraph

Article in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ashutosh TripathiCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, United States of America.
Venkata Sanjeev Kumar NeelaImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Rajesh Kumar RadhakrishnanDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School Medicine, St. Louis, Missouri, United States of America.
Kamakshi Prudhula DevalrajuImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Anvesh Kumar BogamImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Tanmoy MukherjeeCenter for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America.
Varalakshmi MallidiImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Abhinav VankayalapatiDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School Medicine, St. Louis, Missouri, United States of America.
Mohammed Soheb Sadath AnsariImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Carlos AranaDepartment of Immunology, UT Southwestern Medical Center, Dallas, Texas, United States of America.
Sindhu JoshiImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Karan P SinghDepartment of Epidemiology and Biostatistics, The University of Texas at Tyler School of Medicine, Health Science Center, Tyler, Texas, United States of America.
Vijaya Lakshmi ValluriImmunology and Molecular Biology Department, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
Ramakrishna VankayalapatiDivision of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School Medicine, St. Louis, Missouri, United States of America.
Deepak TripathiDepartment of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.ORCID https://orcid.org/0000-0002-5560-2565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We determined whether microRNAs (miRNAs) regulate resistance to Mycobacterium tuberculosis (Mtb) infection in healthy household contacts (HHCs) of patients with tuberculosis (TB). As shown in our previously published study, we recruited 460 HHCs from 443 index cases of active pulmonary TB, with 293 (64.8%) remaining IGRA-negative throughout a two-year follow-up. Whole-transcriptome sequencing at baseline (0 months) and follow-up (24 months) and confirmation studies identified miRNA-1246 (downregulated) and miRNA-125b (upregulated) as potential candidates for the development of resistance in nonconverters compared with converters and progressors. Mechanistic studies using proteomics and computational analysis revealed that miRNA-1246 inhibitor reduce Mtb growth in macrophages by regulating lipase activity, specifically through targeting alpha/beta hydrolase domain-containing protein 2 (ABHD2). Inhibition of miRNA-1246 increased glycolytic activity and promoted a metabolic shift in macrophages conducive to pathogen clearance, suggesting its critical role in metabolic regulation and resistance to tuberculosis. These findings highlight potential miRNA-based therapeutic strategies to enhance immunity against Mtb.

Indexed as

Lipid MetabolismMacrophagesMicroRNAsMycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryFemaleHumansMicroRNAsMIRN1246 microRNA, human

Identifiers

PMID42868206
PMCPMC13660885

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