Evidence map›Paper›PMID 42868112›Full record

ArticleDrug delivery2026

Acid-responsive nanoparticles with microneedles for anti‑inflammatory sonodynamic therapy of gouty arthritis.

Jiaqi Weng, Lili Feng, Binghui Xie, Linxiao Liu, Shulin Shen, Xuechao Chen, Liting Wang, Yueyue Xie, Jianhua Yao, Laurent David and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiaqi WengCollege of Mechanical Engineering, Zhejiang University of Technology, Hangzhou, PR China.
Lili FengDepartment of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School, Shanghai, PR China.
Binghui XieCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Linxiao LiuCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Shulin ShenCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Xuechao ChenCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Liting WangCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Yueyue XieCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.
Jianhua YaoCollege of Mechanical Engineering, Zhejiang University of Technology, Hangzhou, PR China.
Laurent DavidIngénierie des Matériaux Polymères, Université Lyon 1, INSA Lyon, Université Jean Monnet, CNRS, UMR 5223, Villeurbanne, France.
Qinying YanCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathological microenvironment of acute gouty arthritis (AGA) features local tissue acidification and the release of a storm of pro-inflammatory cytokines. To address this dual challenge, we engineered an acid-responsive curcumin-loaded nanoparticles microneedle system (Cur-PNPs@MN) that delivers curcumin with pH-triggered release and anti-inflammatory activity. This integrated platform combines a hyaluronic acid (HA)-based dissolving microneedle for localized transdermal delivery of acid-degradable PCADK (poly (cyclohexane-1,4-diyl acetone dimethylene ketal)) curcumin nanoparticles (Cur-PNPs), which are designed for pH-triggered curcumin release at the pathological site. Together, they deliver curcumin, a dual-function agent acting both as an anti-inflammatory compound and a nanoenhanced sonosensitizer.

Indexed as

Anti-Inflammatory AgentsArthritis, GoutyCurcuminNanoparticlesAdministration, CutaneousAnimalsDrug Delivery SystemsDrug LiberationHyaluronic AcidHydrogen-Ion ConcentrationMacrophagesMaleMiceMicroneedle Drug DeliveryRatsRAW 264.7 CellsAnti-Inflammatory AgentsCurcuminHyaluronic AcidReactive Oxygen Speciesacid-sensitive drug deliverycurcuminGouty arthritismicroneedle drug delivery systemsonodynamic therapy

Identifiers

PMID42868112
PMCPMC13670771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.