Evidence map›Paper›PMID 42868010›Full record

ArticleeLife2026

Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly.

Katherine X Dong, Yanbo Zhang, Hui Ji, David J Luginbuhl, Liqun Luo, Colleen N McLaughlin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katherine X DongDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0009-0003-0613-7454
Yanbo ZhangDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0009-0000-1092-8150
Hui JiDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.
David J LuginbuhlDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.
Liqun LuoDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0001-5467-9264
Colleen N McLaughlinDepartment of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, United States.ORCID https://orcid.org/0000-0002-7518-8920

Funding

Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
Cell surface protein dynamics in neural circuit assemblyK99DC021195 · NIDCD · STANFORD UNIVERSITY · PI MCLAUGHLIN, COLLEEN · 2024 to 2025
$257k
Damon Runyon Cancer Research Foundation DR-2390-20NIDCD NIH HHS K99 DC021195NIDCD NIH HHS K99-DC021195NIDCD NIH HHS R01 DC005982NIDCD NIH HHS R01-DC005982
6 · The paper itself

Abstract

Neural circuit assembly relies on the precise regulation of cell-surface receptors that mediate signaling and adhesion. Endocytosis controls receptor activity and availability by internalizing and routing proteins through early endosomes to one of two main pathways: recycling back to the cell-surface or delivery to lysosomes for degradation. Rab GTPases direct receptors into these distinct pathways, but their specific contributions to circuit formation remain opaque. Using clonal analyses with null alleles, we dissected the roles of Rab-mediated trafficking to early, late, and recycling endosomes across multiple stages of circuit assembly

Indexed as

Drosophila melanogasterDrosophila ProteinsEndosomesNeuronsrab5 GTP-Binding Proteinsrab GTP-Binding ProteinsAnimalsEndocytosisProtein Transportrab11 GTP-Binding ProteinsDrosophila Proteinsrab11 GTP-Binding ProteinsRab11 protein, Drosophilarab5 GTP-Binding ProteinsRab5 protein, Drosophilarab GTP-Binding Proteinscell biologyD. melanogasterendocytosisneural circuit assemblyneural developmentneuroscienceolfactory projection neuronsRab GTPasesrecycling

Identifiers

PMID42868010
PMCPMC13661049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.