Evidence map›Paper›PMID 42867998›Full record

ArticleThe Journal of frailty & aging2026

Reduced total arterial compliance in frail older adults is associated with orthostatic blood pressure variability but not baroreflex sensitivity.

Dihogo Gama de Matos, Felipe J Aidar, Albena Nunes-Silva, Govind Peringod, Vincenzo Giambusso, Roman Romero-Ortuno, Todd A Duhamel, Rodrigo Villar

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Article in The Journal of frailty & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Dihogo Gama de MatosCardiorespiratory & Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.
Felipe J AidarGraduate Program in Physical Education and Kinesiology and Physiological Sciences, Federal University of Sergipe, Sao Cristovao, 49100-000, Brazil.
Albena Nunes-SilvaLaboratory of Inflammation and Exercise Immunology, Department of Physical Education, School of Physical Education, Federal University of Ouro Preto, Ouro Preto, MG, 35400-000, Brazil.
Govind PeringodCumming School of Medicine, University of Calgary, AB, T2N 2T8, Canada.
Vincenzo GiambussoDepartment of Experimental and Clinical Medicine, University of Florence and Careggi University Hospital, Florence, 50134, Italy.
Roman Romero-OrtunoDiscipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, D02 PN40, Ireland.
Todd A DuhamelFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada;; Institute of Cardiovascular Sciences, St. Boniface General Hospital Albrechtsen Research Centre, Winnipeg, MB, Canada.
Rodrigo VillarCardiorespiratory & Physiology of Exercise Research Laboratory, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada;; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada; Centre on Aging, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.. Electronic address: Rodrigo.villar@umanitoba.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal arterial compliance (TAC) reflects arterial elasticity and may be associated with baroreflex sensitivity (BRS) and beat-by-beat blood pressure variability (BPV) during postural transitions. Frailty is also associated with impaired autonomic cardiovascular regulation, which may further compromise blood pressure control during orthostatic stress. However, these relationships have not been investigated in frail older adults. We hypothesized that frail participants would exhibit lower TAC than non-frail participants and that reduced TAC would be associated with impaired autonomic regulation.

methodsCommunity-dwelling older adults aged 60-79 years were classified as non-frail (n=28) or frail (n=22) using the Frailty Index. Participants completed sitting-to-standing and lying-to-standing transitions with continuous cardiovascular monitoring. TAC was estimated as the stroke volume-to-pulse pressure ratio, BRS using the sequence method, and BPV using frequency-domain analysis. General linear models compared TAC between groups. Correlation and regression analyses examined associations between TAC, BRS, and BPV, adjusting for frailty status and medication use.

resultsFrail participants exhibited lower TAC than non-frail participants during both conditions (all p < 0.05). TAC was not associated with BRS during either orthostatic transition (both p > 0.05). In contrast, lower TAC was associated with greater systolic BPV during sitting-to-standing (SBPV-VLF: β = -0.46, p = 0.006) and lying-to-standing (SBPV-VLF: β = -0.60, p < 0.001; SBPV-LF: β = -0.56, p < 0.001; SBPV-HF: β = -0.32, p = 0.04).

conclusionsThese findings suggest that impaired arterial compliance contributes to orthostatic autonomic dysfunction in frail older adults primarily through reduced vascular buffering rather than impaired cardiovagal baroreflex function.

Indexed as

Arterial complianceAutonomic regulationFrailtyPostural transition

Identifiers

PMID42867998
PMCPMC13685980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.