Evidence map›Paper›PMID 42867879›Full record

ArticleeLife2026

Gluconeogenic compensation renders glycogen phosphorylase non-essential as an insecticidal target in

Yifei Zhou, Yanqi Kang, Yan Liu, Ruichi Li, Dongliang Wang, Chong Yi, Yifan Li, Yalin Zhang, Zhen Tian, Jiyuan Liu

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yifei ZhouKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0009-0000-2928-632X
Yanqi KangKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Yan LiuKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Ruichi LiKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Dongliang WangKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Chong YiKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Yifan LiKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Yalin ZhangKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0002-1204-9181
Zhen TianKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.
Jiyuan LiuKey Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0002-3524-2064

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010156Chinese Universities Scientific Fund 2452021151Chinese Universities Scientific Fund 2452022348National Natural Science Foundation of China 32172452National Natural Science Foundation of China 32372626Shenzhen Municipal Fundamental Research Program JCYJ20240813152006009
6 · The paper itself

Abstract

Glycogen phosphorylase (GP) catalyzes the rate-limiting step of glycogenolysis and supplies precursors for chitin biosynthesis in insects. Acyl urea compounds structurally related to benzoylphenylurea (BPU) insecticides are potent inhibitors of mammalian GP, raising the question of whether insect GP could serve as an independent insecticidal target. Here, we show that a mammalian GP inhibitor (GPI) potently inhibits recombinant

Indexed as

Glycogen PhosphorylaseInsecticidesMothsAnimalsEnzyme InhibitorsLarvaMolecular Docking SimulationRNA InterferenceEnzyme InhibitorsGlycogen PhosphorylaseInsecticidesbenzoylphenylureabiochemistrychemical biologyDiamondback mothgluconeogenesisglycogen phosphorylaseinsecticide targetmetabolic compensation

Identifiers

PMID42867879
PMCPMC13661043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.