Evidence map›Paper›PMID 42867810›Full record

ArticleMolecular and cellular biochemistry2026

SUMO2-mediated SP1 SUMOylation promotes M2 macrophage polarization to facilitate diabetic foot ulcer healing.

Ziping Yi, Qin Tao, Wenjian Pan, Xia Yao

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziping Yi *R&D department, Shanghai Xingshi Clinical Laboratory Co., Ltd., No.955 liuxiang highway, Jiading district, Shanghai, 201802, China. ziping.yi@xsbiomed.com.
Qin Tao *Department of Endocrinology, Shanghai Pudong New Area People's Hospital, No. 490, South Chuanhuan Road, Chuansha Town, Pudong New Area, Shanghai, 201299, China.
Wenjian PanR&D department, Shanghai Xingshi Clinical Laboratory Co., Ltd., No.955 liuxiang highway, Jiading district, Shanghai, 201802, China.
Xia YaoDepartment of Endocrinology, Shanghai Pudong New Area People's Hospital, No. 490, South Chuanhuan Road, Chuansha Town, Pudong New Area, Shanghai, 201299, China. yaoxia@shpdph.cn.

Funding

Effect of SGLT-2i Combined with Chiglitazar on Hepatic Steatosis and Fibrosis in Patients with T2DM Complicated with MASLD: A Randomized Controlled Trial E25-01
6 · The paper itself

Abstract

Diabetic foot ulcers (DFU) present a severe clinical challenge, marked by poor healing, chronic inflammation, and elevated amputation risk. The M2 macrophage is known to support the wound healing of DFU, and syndecan-4 (SDC4) contributes to this process. However, the upstream regulatory mechanisms involving post-translational modifications and transcriptional networks remain unclear. The related molecule levels were measured by RT-qPCR and Western blot. The M2 macrophage biomarkers (IL-10, Arg-1) were detected by ELISA kits, while the number of F4/80

Indexed as

Diabetic foot ulcerM2 macrophage polarizationSDC4SP1SUMOylation

Identifiers

PMID42867810

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.