SynthesisCurrent pain and headache reports2026
Pharmacological and Non-Pharmacological approaches to manage Tension-Type Headache: a Systematic Review.
Synthesis in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTension-Type Headaches (TTH), particularly in its chronic form, constitutes a persistent pain syndrome that can substantially impair physical, cognitive, emotional, and social functioning. Although this is the most common type of headache, there is a lack of clear consensus on the optimal long-term treatment strategy.
objectivesA systematic review was conducted to evaluate the evidence for the effectiveness of pharmacological and non-pharmacological treatments in patients diagnosed with episodic or chronic TTH, focusing on improvements in headache pain and related clinical outcomes.
methodsA search across five electronic databases (PubMed, Scopus, Web of Science, Cochrane CENTRAL, and PsycNET) was conducted to identify randomized clinical trials (RCTs). The review was registered in PROSPERO, followed PRISMA guidelines and used the Cochrane Risk of bias 2 tool. Due to significant clinical and methodological heterogeneity, a narrative synthesis was performed following the Synthesis Without Meta-analysis (SWiM) framework, and the certainty of evidence was appraised using the GRADE approach. RESULTS AND
conclusionsNinety-three RCTs were included, most of which had a moderate to low risk of bias. Based on the findings of this systematic review, the evidence suggests that pharmacological, manual, and behavioral therapies each have specific indications. These approaches can be combined in an individualized manner according to each patient's needs, with the aim of maximizing long-term symptom reduction, minimizing side effects, and ultimately improving quality of life in individuals with TTH.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.