Evidence map›Paper›PMID 42867666›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Benefits of optimizing cooperation in head and neck cancer care in a regional referral network.

Henrieke W Schutte, Nilou Labbé, Guido B van den Broek, Jimmie Honings, Henri A M Marres, Willem L J Weijs, Stefan C A Steens, Anne I J Arens, Adriana C H van Engen-van Grunsven, Chantal M L Driessen and 3 more

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Henrieke W SchutteRadboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands. Henrieke.Schutte@radboudumc.nl.ORCID http://orcid.org/0000-0001-9902-8131
Nilou LabbéRadboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.
Guido B van den BroekRadboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.
Jimmie HoningsRadboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.
Henri A M MarresRadboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.
Willem L J WeijsRadboud Institute for Health Sciences, Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
Stefan C A SteensRadboud Institute for Health Sciences, Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Anne I J ArensRadboud Institute for Health Sciences, Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Adriana C H van Engen-van GrunsvenRadboud Institute for Health Sciences, Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Chantal M L DriessenRadboud Institute for Health Sciences, Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Johannes H A M KaandersRadboud Institute for Health Sciences, Department of Radiation Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Robert P Takes *Radboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.
Frank J A van den Hoogen *Radboud Institute for Health Sciences (RIHS), Department of Otorhinolaryngology, Head & Neck Surgery, Radboud University Medical Centre, P.O. Box 9101, Nijmegen, 6500 HB, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReducing the time to treatment improves outcomes, including survival, in patients with head and neck cancer (HNC). After implementing multiple local interventions to optimise organisation of HNC care in a large, recognized head and neck oncological centre (HNOC), this observational study evaluates changes in the diagnostic pathway before the first visit to our HNOC following the implementation of a regional referral agreement within a broader programme of care pathway optimisation.

methodsAll patients with newly diagnosed HNC in 2008 were compared with those diagnosed in 2016 before and after the agreement with referring hospitals to immediately refer patients based on clinical suspicion of cancer and refrain from any additional diagnostic procedures.

resultsOf the 559 patients with suspected HNC who were eligible for inclusion, 266 were included in 2008 and 293 in 2016. The time from the initial consultation with the referring medical specialist to referral to our HNOC decreased significantly from 16 to 11 days (median, p = 0.002). Overall, the interval from the initial consultation with the referring medical specialist to the start of treatment at an HNOC decreased from 56 days to 38 days (median, p < 0.001). Interestingly, this also resulted in a 47.6% decrease in rigid laryngopharyngoscopies and a 38.9% reduction in CT and MR imaging (p < 0.001).

conclusionFollowing the care pathway optimisation, patients started treatment earlier, and the number of diagnostic procedures performed under general anesthesia decreased, reducing associated risks and costs. This study demonstrates that coordinated pathway optimisation at both network and tertiary-centre level may contribute to more efficient oncological care.

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.