ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Impact of early combined oral and intratympanic corticosteroid therapy on hearing outcomes in sudden sensorineural hearing loss: A prospective cohort study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate hearing outcomes following early simultaneous oral and intratympanic corticosteroid therapy in patients with sudden sensorineural hearing loss (SSHL).
methodsA prospective cohort study was conducted including 65 adult patients with SSHL treated with oral prednisone (1 mg/kg/day; maximum 60 mg/day) for 14 days combined with intratympanic methylprednisolone (40 mg/mL) administered weekly for three weeks. The primary outcomes were changes in pure-tone average (PTA; 500-3000 Hz) and speech discrimination score (SDS) at baseline and one month after treatment.
resultsMedian baseline PTA improved from 85 dB to 56 dB one month after treatment, corresponding to a median improvement of 28 dB (p < 0.0001). Median SDS increased from 0% to 80% (p < 0.0001). No statistically significant differences in hearing improvement were observed according to treatment initiation time, age group, or baseline hearing classification.
conclusionEarly simultaneous combined oral and intratympanic corticosteroid therapy was associated with significant improvements in PTA and SDS in this cohort of patients with SSHL without major adverse events observed during follow-up. Further comparative studies are required to better define the role of early combined therapy in SSHL management.
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