Evidence map›Paper›PMID 42867593›Full record

ArticleAnnals of surgical oncology2026

Predictive Factors for Occult Metastases in Clinically M0 Pancreatic Cancer: A Prospective Multicenter Analysis of Staging Laparoscopy.

Masahiro Iseki, Takamichi Igarashi, Ryosuke Takahashi, Masamichi Mizuma, Kyohei Ariake, Kei Nakagawa, Shuichi Aoki, Takayuki Miura, Shimpei Maeda, Masaharu Ishida and 9 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Masahiro IsekiDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takamichi IgarashiDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Ryosuke TakahashiDepartment of Surgery I, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Masamichi MizumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan. masamichi.mizuma.e5@tohoku.ac.jp.
Kyohei AriakeDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kei NakagawaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shuichi AokiDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takayuki MiuraDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shimpei MaedaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masaharu IshidaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuto ShibuyaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Isaku YoshiokaDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Nana KimuraDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Toru WatanabeDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Katsuhisa HiranoDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Shuichiro SugawaraDepartment of Surgery I, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Fuyuhiko MotoiDepartment of Surgery I, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Tsutomu FujiiDepartment of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

KUROKAWA CANCER RESEARCH FOUNDATION Grant-in-Aid
6 · The paper itself

Abstract

backgroundStaging laparoscopy (SL) is a minimally invasive approach for detecting occult metastases in patients with pancreatic cancer (PC) without signs of metastasis on imaging. This study aimed to identify the predictive factors for imaging-negative occult metastases.

methodsThis prospective study enrolled 199 patients with histologically confirmed PC from three institutions between August 2021 and April 2023. All patients were scheduled for a treatment plan that included SL.

resultsThe overall metastasis rate as detected using SL was 25.1%, which varied from 20.6% in patients with resectable PC (R-PC) to 33.8% in those with borderline resectable or locally advanced unresectable PC (BR/URLA-PC). In 152 patients who did not receive neoadjuvant therapy, BR/URLA status (odds ratio 3.261; 95% confidence interval 1.185-9.483, p = 0.022) and pancreatic body/tail lesions (odds ratio 2.653; 95% confidence interval 1.037-7.214, p = 0.042) were independent risk factors for occult metastatic lesions (M1). Among the 107 patients with R-PC, M1 disease was significantly associated with pancreatic body/tail lesions, tumor size, and elevated levels of tumor markers. In particular, elevated carbohydrate antigen 19-9 levels were consistent across all patients with M1 pancreatic head cancer. In contrast, no statistical differences were observed for any of these factors in the 45 patients with BR/URLA-PC.

conclusionsOur findings support the importance of SL in patients with BR/UR PC. For R-PC, patients with pancreatic head lesions and normal tumor marker values may represent a very low-risk subgroup where selective omission of SL can be considered in resource-constrained settings.

Indexed as

DiagnosisLaparoscopyNeoplasm metastasisPancreatic neoplasmsPeritoneal lavage

Identifiers

PMID42867593

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