Evidence map›Paper›PMID 42867547›Full record

ArticleActa neuropathologica2026

CHCHD2 mitigates age-associated proteostatic collapse by maintaining homeostasis of the mitochondria-lysosome axis.

Teresa R Kee, Brianna M Masters, Khoi D Tran, Hanna Jeon, Ma Long, Grace Xu, Sophia A Khan, Edwin Vázquez-Rosa, Preethy S Sridharan, Yeojung Koh and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Teresa R KeeDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Brianna M MastersDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Khoi D TranDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Hanna JeonDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ma LongDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Grace XuDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Sophia A KhanDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Edwin Vázquez-RosaDepartment of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Preethy S SridharanDepartment of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Yeojung KohDepartment of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Hisashi Fujioka *Electron Microscopy Core Facility, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Dale ChaputDepartment of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA.
Xinming WangDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Xingyu ZhaoDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Andrew A PieperDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
David E KangDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. dek94@case.edu.
Jung-A A WooDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. jaw330@case.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7M
Decoding the BETA-arrestin2-LMBRD2 cascade in ALPHA-synuclein pathogenesis.RF1NS134638 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI WOO, JUNGA "ALEXA" · 2024 to 2024
$2.1M
Pathological Signatures of CHCHD10 Dysfunction in ADRDsR01NS122350 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KANG, DAVID E · 2021 to 2025
$2.0M
The role of mitochondrial fission in neurodegeneration in the leading environmental cause of Alzheimer's diseaseF30AG076183 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI SRIDHARAN, PREETHY · 2022 to 2024
$158k
Mechanisms of blood-brain barrier deterioration in vascular cognitive impairment and Alzheimers diseaseF99AG083111 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI KOH, YEO JUNG · 2023 to 2024
$98k
BLRD VA I01 BX005976BLRD VA I01 BX006539NIA NIH HHS F30 AG076183NIA NIH HHS F99 AG083111NIA NIH HHS F99AG083111NIA NIH HHS P50 AG025688NIGMS NIH HHS T32 GM007250NIH HHS F30AG076183NIH HHS R01NS122350NIH HHS RF1NS134638NINDS NIH HHS R01 NS122350NINDS NIH HHS RF1 NS134638Office of Dietary Supplements GM007250U.S. Department of Defense AZ210092/W81XWH-22-1-0129U.S. Department of Veterans Affairs I01BX005976U.S. Department of Veterans Affairs I01BX006539
6 · The paper itself

Abstract

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 2 (CHCHD2), including the Parkinson's disease (PD)-linked CHCHD2

Indexed as

AgingDNA-Binding ProteinsLysosomesMitochondriaMitochondrial ProteinsProteostasisTranscription FactorsAnimalsBrainHomeostasisHumansCHCHD2 protein, humanDNA-Binding ProteinsMitochondrial ProteinsTranscription FactorsAgingCHCHD2Lewy body disordersMitochondria-lysosome axis

Identifiers

PMID42867547
PMCPMC13661657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.