In one paragraphArticle in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Chen-Xuan KangLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0009-0001-4147-6780 Jing-Ya DingLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-5092-7774 Yu-Fang LoLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-1302-0006 Tsai-Yi WuLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0009-0004-8935-7248 Han-Po ShihLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-2247-5467 Jhan-Jie PengLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0001-8923-9234 Kung-Wei LinLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0009-0007-1268-2861 You-Ning LinLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-9063-6453 Chia-Chi LoLaboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0009-0000-4442-2676 Shao-Hsuan HsiaPhysician Assistant Department, University of Maryland Eastern Shore, Princess Anne, MD, USA.ORCID 0009-0005-1928-0959 Jainn-Jim LinDivision of Pediatric Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0001-5592-6343 En-Pei LeeDivision of Pediatric Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0002-4114-5877 Oi-Wa ChanDivision of Pediatric Critical Care Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0002-8470-9505 Yhu-Chering HuangDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0003-4351-8953 Chih-Jung ChenDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0001-5317-2461 Tzou-Yien LinDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0002-6175-2471 Cheng-Lung Ku *Laboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-0643-2256 Chen-Yen Kuo *Laboratory of Human Immunology and Infectious Diseases, Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID 0000-0002-6277-6408 Funding
Chang Gung Memorial Hospital BMRPB98Chang Gung Memorial Hospital CMRPD1K0681National Science and Technology Council 105-2628-B-182-002-MY3
6 · The paper itselfAbstract
Neutralizing autoantibodies (auto-Abs) against type I IFNs (IFN-α and IFN-ω) have emerged as major acquired risk factors for severe viral infections. Human adenovirus (HAdV) is highly prevalent in children and can cause severe pneumonia, but the host determinants of disease severity remain poorly understood. We describe here a 5-year-old child with life-threatening HAdV-B7 pneumonia requiring intensive care who carried high-titer anti-IFN-ω auto-Abs of the IgG1 and IgG3 subclasses. Peripheral blood mononuclear cells produced normal amounts of IFN-α and IFN-ω ex vivo; however, IFN-ω was undetectable in the plasma during acute illness. Functional assays demonstrated that the patient's plasma strongly neutralized IFN-ω, abolishing its antiviral signaling and protective effects, resulting in high levels of adenovirus replication and virus-induced cytotoxicity. These findings implicate anti-IFN-ω auto-Abs in severe adenoviral infection and support immunological screening of pediatric patients with unexplained severe viral pneumonia, which may guide targeted management.
Identifiers
PMID42867380
PMCPMC13660523
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